Porphyrin metabolisms in human skin commensal Propionibacterium acnes bacteria: potential application to monitor human radiation risk.
Porphyrin metabolisms in human skin commensal Propionibacterium acnes bacteria: potential application to monitor human radiation risk.
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DOI：
10.2174/0929867311320040007
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发表时间：
2013
影响因子：
4.1
通讯作者：
Huang CM
中科院分区：
文献类型：
--
作者：
Shu M;Kuo S;Wang Y;Jiang Y;Liu YT;Gallo RL;Huang CM
痤疮丙酸杆菌(P.acnes)是一种革兰氏阳性厌氧菌，是人体皮肤的共生菌。像人类细胞一样，细菌产生卟啉，它显示出荧光特性，并使细菌在伍德灯下可见。在这篇综述中，我们比较了卟啉在人类和痤疮假单胞菌中的生物合成。此外，由于生活在皮肤表面的痤疮假单胞菌受到与人类相同的辐射暴露，我们可以预见，辐射对痤疮假单胞菌的卟啉谱(吸收光谱和/或新陈代谢)的变化可能反映出人类细胞对辐射的反应。痤疮假单胞菌的卟啉谱可能比其他生物剂量计/生物标志物更准确地反映患者的辐射风险，例如基因上调/下调，这可能是由于与患者相关的因素，如自身免疫性疾病而非特异性的。最后，我们讨论了使用痤疮肺炎杆菌的反应来预测辐射风险的挑战和可能的解决方案。
Propionibacterium acnes (P. acnes), a Gram-positive anaerobic bacterium, is a commensal organism in human skin. Like human cells, the bacteria produce porphyrins, which exhibit fluorescence properties and make bacteria visible with a Wood’s lamp. In this review, we compare the porphyrin biosynthesis in humans and P. acnes. Also, since P. acnes living on the surface of skin receive the same radiation exposure as humans, we envision that the changes in porphyrin profiles (the absorption spectra and/or metabolism) of P. acnes by radiation may mirror the response of human cells to radiation. The porphyrin profiles of P. acnes may be a more accurate reflection of radiation risk to the patient than other biodosimeters/biomarkers such as gene up-/down-regulation, which may be non-specific due to patient related factors such as autoimmune diseases. Lastly, we discuss the challenges and possible solutions for using the P. acnes response to predict the radiation risk.