Relationship of physical activity with physical function and health-related quality of life in patients having undergone allogeneic haematopoietic stem-cell transplantation
Relationship of physical activity with physical function and health-related quality of life in patients having undergone allogeneic haematopoietic stem-cell transplantation
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DOI：
10.1111/ecc.12669
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发表时间：
2017-07-01
影响因子：
2.1
通讯作者：
Domen, K.
中科院分区：
文献类型：
--
作者：
Morishita, S.;Kaida, K.;Domen, K.
在这项研究中，我们调查了30例接受异基因造血干细胞移植（allo-HSCT）的患者移植前后体力活动的差异，以及体力活动与身体功能和健康相关生活质量（QOL）之间的关系。使用三维加速度计量化身体活动的持续时间和强度。身体功能通过握力和膝伸肌力量进行量化，6分钟步行试验（6 MWT）用作运动能力的测量。使用36项健康简表调查评估健康相关QOL。在allo-HSCT后，以>3.0代谢当量（MET）的强度进行的日常活动的比例显著增加（p <0.05）。在1.6-2.9 MET强度下进行的日常活动时间仅与左膝强度显著相关（p <0.05）。相比之下，每日总步数和在1.6-2.9 MET和>3.0 MET下进行的活动比例与6 MWT呈正相关（p <0.05）。此外，健康相关QOL中的身体功能和一般健康子量表与>3.0 MET的日常活动呈正相关（p < .05）。体力活动与6 MWT和健康相关QOL相关。这些发现对接受allo-HSCT的患者的康复计划具有重要意义。
In this study, we investigated the differences in physical activity before and after transplantation, and the relationship between physical activity and physical function and health-related quality of life (QOL) in 30 patients who underwent allogeneic haematopoietic stem cell transplantation (allo-HSCT). Duration and intensity of physical activity were quantified using a three-dimensional accelerometer. Physical function was quantified by handgrip and knee-extensor strength, with the 6-minute walk test (6MWT) used as a measure of exercise capacity. Health-related QOL was assessed using the 36-item Short-Form Health Survey. The proportion of daily activities performed at an intensity >3.0 metabolic equivalents (METs) increased significantly after allo-HSCT (p < .05). Daily activity time performed at an intensity of 1.6-2.9 METs significantly correlated only with left knee strength (p < .05). In contrast, the total number of daily steps and the proportion of activity performed at 1.6-2.9 METs and >3.0 METs were positively correlated with the 6MWT (p < .05). Additionally, physical functioning and general health subscales in health-related QOL positively correlated with daily activities performed at >3.0 METs (p < .05). Physical activity was associated with 6MWT and health-related QOL. These findings have implications for rehabilitation planning for patients undergoing allo-HSCT.