Arousal response to hypoxia in newborn mice
Arousal response to hypoxia in newborn mice
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DOI：
10.1016/s0034-5687(01)00303-6
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发表时间：
2001-11-01
期刊：
影响因子：
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通讯作者：
Gallego, J
中科院分区：
文献类型：
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作者：
Dauger, S;Aizenfisz, S;Gallego, J
我们检查了新生小鼠在外周化学感受器重置之前和之后的几个年龄段对 5% O-2 的唤醒反应，即 3、12 和 48 小时（每组 n = 22）。通过全身流量气压体积描记法测量呼吸。睡眠和觉醒是由行为决定的。我们发现：（1）所有年龄组都存在唤醒反应；（2）所有年龄组的缺氧通气下降期间都出现唤醒反应，表明机械感受器输入不足以触发唤醒；（3）化学感受器重置后的唤醒潜伏期比化学感受器重置前短，表明化学感受器对唤醒的贡献。我们的结论是，唤醒可能导致小鼠出生后早期的缺氧通气反应，并且在新生儿通气控制成熟的研究中应考虑到这一点。 (C) 2001 Elsevier Science B.V. 保留所有权利。
We examined the arousal response to 5% O-2 in newborn mice at several ages before and after peripheral chemoreceptor resetting namely, at 3, 12, and 48 h (n = 22 in each group). Breathing was measured by whole-body flow barometric plethysmography. Sleep and arousal were determined behaviourally. We found that: (1) the arousal response was present in all age groups: (2) the arousal response occurred during the hypoxic ventilatory decline in all age groups, showing that mechanoreceptor input was not sufficient to trigger arousal: and (3) arousal latency was shorter after than before chemoreceptor resetting, suggesting a contribution of chemoreceptors to arousal. We conclude that arousal may contribute to the hypoxic ventilatory response in the early postnatal period in mice and that it should be taken into consideration in studies of ventilatory control maturation in newborns. (C) 2001 Elsevier Science B.V. All rights reserved.