Transfer of Quantum Dots from Pregnant Mice to Pups Across the Placental Barrier
Transfer of Quantum Dots from Pregnant Mice to Pups Across the Placental Barrier
复制标题
量子点从怀孕小鼠身上穿过胎盘屏障转移到幼崽身上
DOI：
10.1002/smll.200902049
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发表时间：
2010-03-08
期刊：
影响因子：
13.3
通讯作者：
Sheng, Lingyi
中科院分区：
文献类型：
--
作者：
Chu, Maoquan;Wu, Qiang;Sheng, Lingyi
荧光量子点在体内生物医学成像和诊断应用中具有巨大的潜力。然而，这些纳米颗粒由重金属组成，直径非常小，因此必须考虑其可能的毒性。到目前为止，还没有研究报道量子点在母亲和胎儿之间的转移。研究了不同尺寸、不同剂量、不同外包覆材料的CdTe/CdS量子点从孕鼠体内向胎鼠体内的转移。结果表明，量子点可以通过胎盘屏障从雌性小鼠转移到其胎儿。较小的量子点比较大的量子点更容易转移，并且转移的量子点的数量随着剂量的增加而增加。用无机硅壳或有机聚乙二醇封端可减少QD的转移，但不能消除它。这些结果表明，QD在孕妇中的临床应用可能受到限制。
Fluorescent quantum dots (QDs) have great potential for in vivo biomedical imaging and diagnostic applications. However, these nanoparticles are composed of heavy metals and are very small in diameter, and their possible toxicity must therefore be considered. As yet, no studies have reported the transfer of QDs between mother and fetus. The transfer of CdTe/CdS QDs of different sizes and dosages, and with different outer capping materials, from pregnant mice to fetuses is investigated. It is shown that QDs may be transferred from female mice to their fetuses across the placental barrier. Smaller QDs are more easily transferred than larger QDs and the number of QDs transferred increases with increasing dosage. Capping with an inorganic silica shell or organic polyethylene glycol reduces QD transfer but does not eliminate it. These results suggest that the clinical utility of QDs could be limited in pregnant women.