Sensorimotor Cortex GABA Moderates the Relationship between Physical Exertion and Assessments of Effort
Sensorimotor Cortex GABA Moderates the Relationship between Physical Exertion and Assessments of Effort
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DOI：
10.1523/jneurosci.2255-21.2022
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发表时间：
2022-08-03
影响因子：
5.3
通讯作者：
Chib, Vikram S.
中科院分区：
文献类型：
--
作者：
Hu, Eric J.;Casamento-Moran, Agostina;Chib, Vikram S.
体力消耗的经验指导我们对努力的评估。虽然这些评估对我们参与日常活动的决定产生了重要影响，但人们对它们是如何产生的知之甚少。我们让女性和男性参与者施加握力，并评估这些努力的感觉;并使用磁共振光谱测量他们的大脑GABA浓度。我们发现运动的可变性（即，他们用力曲线的变异系数）与努力评估的增加有关，使参与者判断努力的代价更高。感觉运动皮层（SM 1）中的GABA水平调节了过度评估努力的影响。在具有较高感觉运动GABA的个体中，运动变异性对过度评估努力的影响减小。从本质上讲，感觉运动GABA有保护作用的影响，努力评估的通货膨胀的努力的变化。我们的发现提供了一个神经生物学的解释，说明大脑是如何？的γ-氨基丁酸能系统集成功能的体力消耗判断的努力，以及如何基本的感觉运动属性可能会影响高阶判断的努力。
Experiences of physical exertion guide our assessments of effort. While these assessments critically influence our decisions to engage in daily activities, little is known about how they are generated. We had female and male human participants exert grip force and assess how effortful these exertions felt; and used magnetic resonance spectroscopy to measure their brain GABA concentration. We found that variability in exertion (i.e., the coefficient of variation in their force exertion profile) was associated with increases in assessments of effort, making participants judge efforts as more costly. GABA levels in the sensorimotor cortex (SM1) moderated the influence of exertion variability on overassessments of effort. In individuals with higher sensorimotor GABA, exertion variability had a diminished influence on overassessments of effort. Essentially, sensorimotor GABA had a protective effect on the influence of exertion variability on inflations of effort assessment. Our findings provide a neurobiological account of how the brain???s GABAergic system integrates features of physical exertion into judgments of effort, and how basic sensorimotor properties may influence higher-order judgments of effort.