Papillary thyroid microcarcinoma: Prognostic factors and treatment
Papillary thyroid microcarcinoma: Prognostic factors and treatment
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DOI：
10.1002/jso.20935
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发表时间：
2008-03-01
影响因子：
2.5
通讯作者：
Zgajnar, Janez
中科院分区：
文献类型：
--
作者：
Besic, Nikola;Pilko, Gasper;Zgajnar, Janez
背景与目的：在甲状腺乳头状微小癌（PTMC）患者组中，预后因素尚未得到很好的定义，最佳治疗尚未得到证实。本研究的目的是找出与肿瘤复发的PTMC.Methods患者的相关因素：共228例PTMC患者（189名女性，39名男性;年龄14-85岁，中位数46岁）在我院治疗1975年和2006年之间。收集患者的性别、年龄、疾病程度、病理形态学特征、治疗、局部控制、无病生存和疾病特异性生存等数据。采用单因素和考克斯多因素生存分析法分析可能的预后因素与无病期的相关性。中位观察时间为84个月（范围1-385）。在随访期间，7例患者（6例局部复发，1例远处复发）被诊断为复发。多因素分析显示，肿瘤大小和淋巴结转移是影响无病期的独立预后因素。结论：肿瘤直径越大，无病期越长
Background and Objectives: Within the group of patients with papillary thyroid microcarcinoma (PTMC), the prognostic factors have not been well defined and the optimal treatment has not been proved. The aim of this study was to find out the factors associated with the tumor recurrence in the patients with PTMC.Methods: A total of 228 patients with PTMC (189 females, 39 males; age 14-85 years, median 46 years) were treated at our Institute between 1975 and 2006. The data on patients' gender, age, extent of disease, pathomorphological characteristics, therapy, locoregional control, disease-free survival and disease-specific survival were collected. Statistical correlation between possible prognostic factors and the duration of disease-free interval was analyzed by univariate and Cox's multivariate survival analysis.Results: The tumor diameter ranged from 0.1 to 10 mm (mean 6.1 mm). The median length of observation was 84 months (range 1-385). During the follow-up period, the recurrence was diagnosed in 7 patients (6 locoregional and I distant). Multivariate analysis showed that tumor size and lymph node metastases were independent prognostic factors for disease-free interval.Conclusions: Longer disease-free interval was found in the patients with a tumor diameter