Error-related brain activity as a transdiagnostic endophenotype for obsessive-compulsive disorder, anxiety and substance use disorder
Error-related brain activity as a transdiagnostic endophenotype for obsessive-compulsive disorder, anxiety and substance use disorder
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DOI：
10.1017/s0033291719000199
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发表时间：
2019-05-01
影响因子：
6.9
通讯作者：
Kathmann, Norbert
中科院分区：
文献类型：
--
作者：
Riesel, Anja;Klawohn, Julia;Kathmann, Norbert
背景：在强迫症（OCD）、焦虑症中观察到神经错误信号的增加，而在抑郁症中则不一致。在物质使用障碍（SUD）中观察到神经错误信号减少。因此，错误监测的改变被认为是一种跨诊断的内表型。为了加强这一概念，需要来自具有各自疾病家族史的未受影响个体的数据。方法选取117名强迫症患者、50名未受影响的强迫症患者一级亲属和130名健康对照者，在侧卫任务中测量错误相关负性（ERN）作为错误监测的神经指标。家族史资料显示，76名健康对照者无精神病理家族史，而其余的一级亲属有抑郁症（n = 28）、焦虑症（n = 27）和/或SUD （n = 27）。结果强迫症患者及未受影响的强迫症患者一级亲属的ERN振幅均升高。此外，焦虑障碍个体的未受影响的一级亲属也表现为ERN振幅增加，而SUD个体的亲属则表现为振幅降低。结论：具有强迫症、焦虑或SUD家族史的未受影响的一级亲属的神经错误信号的改变支持了ERN作为一种跨诊断的内表型的效用。神经错误信号的减少可能表明易受控制的行为和物质使用的风险，而伤害或避免错误的反应风格和易受强迫症和焦虑的影响似乎与ERN增加有关。这进一步表明，在涉及前扣带皮层和认知控制缺陷的精神疾病中，存在一个共同的神经生物学基础。
BackgroundIncreased neural error-signals have been observed in obsessive-compulsive disorder (OCD), anxiety disorders, and inconsistently in depression. Reduced neural error-signals have been observed in substance use disorders (SUD). Thus, alterations in error-monitoring are proposed as a transdiagnostic endophenotype. To strengthen this notion, data from unaffected individuals with a family history for the respective disorders are needed.MethodsThe error-related negativity (ERN) as a neural indicator of error-monitoring was measured during a flanker task from 117 OCD patients, 50 unaffected first-degree relatives of OCD patients, and 130 healthy comparison participants. Family history information indicated, that 76 healthy controls were free of a family history for psychopathology, whereas the remaining had first-degree relatives with depression (n = 28), anxiety (n = 27), and/or SUD (n = 27).ResultsIncreased ERN amplitudes were found in OCD patients and unaffected first-degree relatives of OCD patients. In addition, unaffected first-degree relatives of individuals with anxiety disorders were also characterized by increased ERN amplitudes, whereas relatives of individuals with SUD showed reduced amplitudes.ConclusionsAlterations in neural error-signals in unaffected first-degree relatives with a family history of OCD, anxiety, or SUD support the utility of the ERN as a transdiagnostic endophenotype. Reduced neural error-signals may indicate vulnerability for under-controlled behavior and risk for substance use, whereas a harm- or error-avoidant response style and vulnerability for OCD and anxiety appears to be associated with increased ERN. This adds to findings suggesting a common neurobiological substrate across psychiatric disorders involving the anterior cingulate cortex and deficits in cognitive control.