Putative multifunctional signature of lung metastases in dedifferentiated chondrosarcoma.
Putative multifunctional signature of lung metastases in dedifferentiated chondrosarcoma.
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作者：
Malchenko S;Seftor EA;Nikolsky Y;Hasegawa SL;Kuo S;Stevens JW;Poyarkov S;Nikolskaya T;Kucaba T;Wang M;Abdulkawy H;Casavant T;Morcuende J;Buckwalter J;Hohl R;Deyoung B;Kernstine K;Bonaldo Mde F;Hendrix MJ;Soares MB;Soares VM
软骨肉瘤是最恶性的骨骼肿瘤之一。去分化软骨肉瘤是软骨肉瘤的一种高度侵袭性亚型，90% 的患者在诊断后几个月内发生肺转移。在本文中，我们对从去分化软骨肉瘤患者手术切除的五个单独的转移性肺部病灶的转录组进行了比较分析。我们首次记录了个体肺转移瘤之间基因表达谱的高度异质性。此外，我们揭示了在所有转移性肺部病变中表达的“多功能”基因的特征。此外，我们首次记录了去分化软骨肉瘤肺转移中大量巨噬细胞浸润的发生。
Chondrosarcomas are among the most malignant skeletal tumors. Dedifferentiated chondrosarcoma is a highly aggressive subtype of chondrosarcoma, with lung metastases developing within a few months of diagnosis in 90% of patients. In this paper we performed comparative analyses of the transcriptomes of five individual metastatic lung lesions that were surgically resected from a patient with dedifferentiated chondrosarcoma. We document for the first time a high heterogeneity of gene expression profiles among the individual lung metastases. Moreover, we reveal a signature of “multifunctional” genes that are expressed in all metastatic lung lesions. Also, for the first time, we document the occurrence of massive macrophage infiltration in dedifferentiated chondrosarcoma lung metastases.