Sublethal exposure to crude oil during embryonic development alters cardiac morphology and reduces aerobic capacity in adult fish
Sublethal exposure to crude oil during embryonic development alters cardiac morphology and reduces aerobic capacity in adult fish
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DOI：
10.1073/pnas.1019031108
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发表时间：
2011-04-26
影响因子：
11.1
通讯作者：
Incardona, John P.
中科院分区：
文献类型：
--
作者：
Hicken, Corinne E.;Linbo, Tiffany L.;Incardona, John P.
暴露于高浓度原油会导致鱼类胚胎出现致命的心力衰竭综合征。多环芳烃（PAHs）是石油中无处不在的成分，对心脏有毒性，是导致死亡的原因。在这里，我们表明，短暂的胚胎暴露于极低浓度的石油造成的毒性是亚致死的，延迟的，而不是抵消细胞色素P450诱导的保护作用。在胚胎油暴露近一年后，成年斑马鱼的心脏形状发生了微妙的变化，游泳能力显著下降，表明心输出量减少。这些对生命后期心血管功能的延迟生理影响提供了一种潜在机制，将个体存活率降低与鱼类种群对慢性低水平石油污染的生态系统反应联系起来。
Exposure to high concentrations of crude oil produces a lethal syndrome of heart failure in fish embryos. Mortality is caused by cardiotoxic polycyclic aromatic hydrocarbons (PAHs), ubiquitous components of petroleum. Here, we show that transient embryonic exposure to very low concentrations of oil causes toxicity that is sublethal, delayed, and not counteracted by the protective effects of cytochrome P450 induction. Nearly a year after embryonic oil exposure, adult zebrafish showed subtle changes in heart shape and a significant reduction in swimming performance, indicative of reduced cardiac output. These delayed physiological impacts on cardiovascular performance at later life stages provide a potential mechanism linking reduced individual survival to population-level ecosystem responses of fish species to chronic, low-level oil pollution.