Brain remodeling after chronic median nerve compression in a rat model.
Brain remodeling after chronic median nerve compression in a rat model.
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大鼠模型慢性正中神经受压后的脑重塑
DOI：
10.4103/1673-5374.230298
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发表时间：
2018-04
影响因子：
6.1
通讯作者：
Zheng XY
中科院分区：
文献类型：
--
作者：
Bao BB;Qu DQ;Zhu HY;Gao T;Zheng XY
腕管综合征是最常见的压迫性神经病，表现为感觉运动功能障碍。在腕管综合征患者中，功能磁共振成像上的不规则传入信号与周围神经损伤期间神经可塑性的变化相关。然而，在临床上很难获得大脑的多点神经影像数据。本研究采用正中神经结扎法建立大鼠正中神经卡压模型，腕管综合征模型。分别于术后2周和2个月，通过功能磁共振成像检测正常大鼠和腕管综合征模型大鼠感觉皮质的重建情况。电刺激双侧爪30秒，与30秒的休息期交替（重复3次），导致正常大鼠对侧感觉运动皮层激活。当腕管综合征大鼠接受这种刺激时，对侧大脑半球在术后2周显著激活，包括初级运动皮层、小脑和丘脑。此外，这种激活在术后2个月时不可见。这些结果表明，大脑皮层的显着重塑出现在正中神经压迫后2周和2个月。
Carpal tunnel syndrome is the most common compressive neuropathy, presenting with sensorimotor dysfunction. In carpal tunnel syndrome patients, irregular afferent signals on functional magnetic resonance imaging are associated with changes in neural plasticity during peripheral nerve injury. However, it is difficult to obtain multi-point neuroimaging data of the brain in the clinic. In the present study, a rat model of median nerve compression was established by median nerve ligation, i.e., carpal tunnel syndrome model. Sensory cortex remodeling was determined by functional magnetic resonance imaging between normal rats and carpal tunnel syndrome models at 2 weeks and 2 months after operation. Stimulation of bilateral paws by electricity for 30 seconds, alternating with 30 seconds of rest period (repeatedly 3 times), resulted in activation of the contralateral sensorimotor cortex in normal rats. When carpal tunnel syndrome rats received this stimulation, the contralateral cerebral hemisphere was markedly activated at 2 weeks after operation, including the primary motor cortex, cerebellum, and thalamus. Moreover, this activation was not visible at 2 months after operation. These findings suggest that significant remodeling of the cerebral cortex appears at 2 weeks and 2 months after median nerve compression.
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影响因子：
6.1
作者：
Chen Y;Zhao CQ;Ye G;Liu CD;Xu WD
通讯作者：
Xu WD
影响因子：
1.9
作者：
Papanicolaou, GD;McCabe, SJ;Firrell, J
通讯作者：
Firrell, J
影响因子：
1.1
作者：
Maeda, Yumi;Kettner, Norman;Napadow, Vitaly
通讯作者：
Napadow, Vitaly
影响因子：
14.5
作者：
Maeda, Yumi;Kettner, Norman;Napadow, Vitaly
通讯作者：
Napadow, Vitaly
影响因子：
3
作者：
Grace, Peter M.;Hutchinson, Mark R.;Rolan, Paul E.
通讯作者：
Rolan, Paul E.