Effects of perceived stress and uplifts on inflammation and coagulability
Effects of perceived stress and uplifts on inflammation and coagulability
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DOI：
10.1111/j.1469-8986.2006.00480.x
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发表时间：
2007-01-01
期刊：
影响因子：
3.7
通讯作者：
Dimsdale, Joel E.
中科院分区：
文献类型：
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作者：
Jain, Shamini;Mills, Paul J.;Dimsdale, Joel E.
我们研究了在108名健康个体中，抑郁情绪、慢性困扰和情绪升高是否能预测止血标志物d -二聚体和1型纤溶酶原激活物抑制剂（PAI-1）以及促炎标志物白介素-6 （IL-6）和可溶性细胞间粘附分子-1 （sICAM-1）的水平。108名非裔美国人和欧美人被研究（男性58人，女性50人，平均年龄= 36.5±8岁）。分析空腹静脉血d -二聚体、PAI-1、IL-6和sICAM-1的血浆水平。数据分析采用层次线性回归，然后进行偏相关分析。回归分析结合偏相关分析表明，争吵频率的增加预示着sICAM-1水平的升高（p = 0.034），争吵严重程度的增加预示着d -二聚体水平的升高（p = 0.017）。隆升强度的增加预示着PAI-1水平的降低（p = 0.004）， IL-6水平的降低（p = 0.069）。抑郁情绪对任何因变量均无显著预测作用。这些结果不受社会人口统计学、生物学和其他相关情绪变量的影响。研究结果表明，即使是相对健康的人，对烦恼的感知增加与更大的炎症和高凝性独立相关，而对兴奋的感知增加与高凝性降低独立相关。
We investigated whether depressed mood and chronic hassles and uplifts predicted levels of hemostasis markers D-Dimer and type-1 plasminogen activator inhibitor (PAI-1), as well as the proinflammatory markers interleukin-6 (IL-6) and soluble intercellular adhesion molecule-1 (sICAM-1) in 108 healthy individuals. One hundred eight African-American and Euro-American men and women were studied (58 men, 50 women; mean age = 36.5 +/- 8 years). D-Dimer, PAI-1, IL-6, and sICAM-1 plasma levels were analyzed from fasting venous blood samples. Data were analyzed via hierarchical linear regression and followed with partial correlation analysis. Regression analyses combined with partial correlation analyses suggested that increases in hassle frequency predicted elevated levels of sICAM-1 (p =.034), and increases in hassle severity predicted elevated levels of D-Dimer (p =.0 17). Increases in uplift intensity predicted lower levels of PAI-1 (p =.004) as well as showed a trend for decreased IL-6 (p =.069). Depressed mood did not significantly predict any dependent variable. These results were independent of sociodemographic, biological, and other related mood variables. The findings suggest that for even relatively healthy persons, increased perceptions of hassles are independently associated with greater inflammation and hypercoagulability, whereas increased perceptions of uplifts are independently associated with decreased hypercoagulability.