TRANSITION FROM T CELL PROTECTION TO T CELL ENHANCEMENT DURING TUMOR GROWTH IN AN ALLOGENEIC HOST
TRANSITION FROM T CELL PROTECTION TO T CELL ENHANCEMENT DURING TUMOR GROWTH IN AN ALLOGENEIC HOST
复制标题
同种异体宿主肿瘤生长期间从 T 细胞保护到 T 细胞增强的转变
DOI：
10.1097/00007890-197610000-00007
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发表时间：
1976
期刊：
影响因子：
6.2
通讯作者：
M. Feldman
中科院分区：
文献类型：
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作者：
Yossef Manor;A. Treves;I. Cohen;M. Feldman
摘要在肿瘤发生过程中，研究了小鼠对致死性同种异体肿瘤的细胞免疫反应。将荷瘤小鼠的脾细胞与3LL肿瘤细胞一起转移到正常C3H/EB受体小鼠体内，研究它们的活性。这种活性依赖于接种肿瘤和转移之间的时间间隔。较早取脾细胞，在肿瘤接种后1周，介导对肿瘤生长的保护作用。相反，肿瘤接种后4周取脾细胞明显促进肿瘤生长。与肿瘤保护细胞一样，增强肿瘤的细胞似乎是T淋巴细胞。通过孵育增强的T细胞而制备的胞外培养液可以传递增强活性。保护性T细胞制备的无细胞培养液不能转移保护性T细胞活性。在正常小鼠的脾细胞群中，这两种活性都被发现存在相对轻微的程度。从T细胞保护到T细胞增强的转变可能是宿主-肿瘤关系结果的决定性因素。
SUMMARY The cell-mediated immune response of mice toward a lethal allogeneic tumor was investigated during tumor development. The activity of spleen cells from the tumor-bearing mice was studied by transferring them together with 3LL tumor cells into normal C3H/eb recipient mice. The activity depended upon the time interval between inoculation of the tumor and transfer. Spleen cells taken relatively early, 1 week after tumor inoculation, mediated protection against tumor growth. In contrast, spleen cells taken 4 weeks after tumor inoculation markedly enhanced tumor growth. The tumor-enhancing cells, like the tumor-protecting cells, appeared to be T lymphocytes. The enhancing activity could be transferred by extracellular medium prepared by incubating the enhancing T cells. Protecting activity could not be transferred by cell-free medium prepared from the protecting T cells. Both activities were found to exist to a relatively slight degree in populations of spleen cells from normal mice. The transition from T cell protection to T cell enhancement might be a determining factor in the outcome of the host-tumor relationship.