Response of pulmonary rapidly adapting receptors during lung inflation.
Response of pulmonary rapidly adapting receptors during lung inflation.
复制标题
肺膨胀期间肺快速适应受体的反应。
DOI：
10.1152/jappl.1983.55.3.955
复制
发表时间：
1983
期刊：
影响因子：
--
通讯作者：
DeLaney,RG
中科院分区：
文献类型：
--
作者：
Pack,AI;DeLaney,RG
本研究旨在探讨犬肺快速适应受体（RAR）在肺膨胀过程中的反应。以几个恒定速率进行肺充气，在此期间对个体RAR的活性进行计数。在每种充盈速率下，进行了多次相同的试验。控制每次测试充气的体积。将在每个流速下的所有测试中获得的数据平均，以给出在该膨胀速率下受体的平均响应。这些研究表明在肺力学相对恒定的条件下，RAR在肺膨胀期间的主要响应特征。首先，在恒定的充气速率下，RAR的活性随着肺的扩张而增加。其次，它们的活动明显受到通货膨胀率的影响。然而，这种灵敏度是非线性的。具体而言，在低膨胀率下，流速的增加比在较高膨胀率下流速的相同增加产生更显著的RAR击发增强。受体之间的主要差异在于它们的阈值;然而，这也是流速的函数。随着流速的增加，阈值，无论是作为膨胀体积还是作为感受器开始激发时的经尿道压力来测量，都下降。然而，在整个范围内具有阈值的受体的响应显示了上面讨论的主要特征。目前的结果提供了定量信息，这是必要的开始，以逃避这种受体类型的转导特性。
Studies were conducted to establish the factors that determine the response of canine pulmonary rapidly adapting receptors (RAR) during lung inflation. Inflations of the lung were performed at several constant rates during which the activity of individual RAR was counted. At each rate of inflation tested multiple identical tests were performed. The volume of each test inflation was controlled. Data obtained in all tests at each flow rate were averaged to give the mean response of the receptor at that rate of inflation. These studies indicate the major response characteristics of RAR during lung inflation in conditions of relatively constant lung mechanics. First, at a constant rate of inflation, the activity of RAR augments increasingly as the lung is expanded. Second, their activity is influenced markedly by the rate of inflation. However, this sensitivity is nonlinear. Specifically, at low rates of inflation increases in flow rate produce more marked augmentation of RAR firing than do identical increases in flow at higher rates of inflation. The major difference between receptors is in their threshold; however, this too is a function of flow rate. With increasing flow rate the threshold, whether measured as the inflation volume or transpulmonary pressure at which receptors begin to fire, declines. The response of receptors, however, with thresholds over the entire range show the major features discussed above. The present results provide quantitative information which are necessary to begin to eludicate the transduction properties of this receptor type.