Environmental Factors in the First Trimester and Risk of Oral-Facial Clefts in the Offspring
Environmental Factors in the First Trimester and Risk of Oral-Facial Clefts in the Offspring
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DOI：
10.1177/1933719112466311
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发表时间：
2013-07
影响因子：
2.9
通讯作者：
M. Chung;T. Lao;Y. Ting;T. Leung;T. Lau;Tze-Wai Wong
中科院分区：
文献类型：
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作者：
M. Chung;T. Lao;Y. Ting;T. Leung;T. Lau;Tze-Wai Wong
在2002-2009年间，平均每个月妊娠的非综合征/孤立性唇裂(CL)、腭裂(CP)和唇裂合并腭裂(CLCP)的发生率与阳光、紫外线、环境氮氧化物(氮氧化物、氮氧化物和二氧化氮)、二氧化硫和臭氧的报道水平相关，在妊娠月，然后在怀孕4周和8周。其中CL 25例，CP 12例，CLCP 22例，共59例，占1.21/1000。回归分析显示，妊娠后4周(P=0.009)、4周(P=0.005)、8周(P=0.008)，日照与游离CL呈负相关，8周时与CP(P=0.009)、CLCP(P<；.001)呈负相关，而NOx与CL(P=0.018)、NO(P=0.031)呈负相关。我们的结果表明，阳光和氮氧化物与其他因素的相互作用导致了报告的孤立性口腔-面裂发病率的季节性变化。
The averaged incidences of nonsyndromal/isolated cleft lip (CL), cleft palate (CP), and cleft lip with cleft palate (CLCP) by each month-of-conception, and managed in our hospital in from 2002 to 2009 were correlated with the reported levels of sunshine, ultraviolet radiation, and ambient nitrogen oxides (nitrogen oxide, nitrogen monoxide, and nitrogen dioxide), sulfur dioxide, and ozone, at the month of, and then at 4 and 8 weeks after, conception. There were 25, 12, and 22 cases each of CL, CP, and CLCP, respectively, totaling 59 cases (1.21 of 1000 births). On regression analysis, sunshine correlated inversely with the isolated CL at (P = .009) 4 weeks (P = .005) and 8 weeks (P = .008) postconception, and with CP (P = .009) and CLCP (P < .001) at 8 weeks postconception, while NOx correlated inversely with CL (P = .018) and NO with CLCP (P = .031), at 8 weeks postconception. Our results suggested that the interaction between sunshine and nitrogen oxides with other factors results in the reported seasonal variation in the incidence of isolated oral-facial clefts.