Thyroid status, insulin sensitivity and glucose tolerance in overweight and obese adults before and after 36 weeks of whey protein supplementation and exercise training.
Thyroid status, insulin sensitivity and glucose tolerance in overweight and obese adults before and after 36 weeks of whey protein supplementation and exercise training.
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DOI：
10.3109/07435800.2015.1094083
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发表时间：
2016-05
影响因子：
2.1
通讯作者：
Campbell WW
中科院分区：
文献类型：
--
作者：
Wright CS;Craddock A;Weinheimer-Haus EM;Lim E;Conley TB;Janle EM;Campbell WW
Research suggests that subclinical hypothyroidism influences insulin sensitivity and glucose tolerance. Reductions in thyroid stimulating hormone concentrations are associated with exercise training, which improves insulin sensitivity and glucose uptake. A secondary analysis of a previously published data was conducted to examine the relationship between subclinical hypothyroidism, thyroid stimulating hormone, and glucose homeostatic control at baseline and to assess the impact of exercise training on thyroid status and how subclinical hypothyroidism affects changes in insulin sensitivity after exercise training. Data were obtained from a 36-week exercise training and whey protein supplementation intervention trial. Subjects (n = 304, 48 ± 7 years, females = 186) were randomized to a specific whey protein group (0g, 20g, 40g, or 60g per day) and all subjects participated in a resistance (2 d/wk) and aerobic (1 d/wk) training program. Testing was conducted at baseline and post-intervention. At baseline, 36% (n=110) and 12% (n=35) of subjects were classified with subclinical hypothyroidism based on the thyroid stimulating hormone ≥ 3μIU/L or thyroid stimulating hormone ≥ 4.5μIU/L cut-offs, respectively. No association was found between baseline thyroid stimulating hormone and baseline measures of glucose homeostatic control. Whey protein supplementation did not influence intervention outcomes. Post-intervention (n=164), no change was observed in thyroid stimulating hormone. Subclinical hypothyroidism did not affect changes in insulin sensitivity following exercise training. These results support that the health benefits of exercise training for the management of insulin resistance are not blunted by subclinical hypothyroidism.
