Exploring the relationship between gut microbiota and exercise: short-chain fatty acids and their role in metabolism.
Exploring the relationship between gut microbiota and exercise: short-chain fatty acids and their role in metabolism.
复制标题
探索肠道微生物群与运动之间的关系：短链脂肪酸及其在代谢中的作用。
DOI：
10.1136/bmjsem-2020-000930
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发表时间：
2021
影响因子：
4.8
通讯作者：
Montag D
中科院分区：
文献类型：
--
作者：
Carey RA;Montag D
人体是肠道中大量细菌、真菌、病毒和其他物种的宿主，统称为微生物群。绕过消化和吸收的膳食碳水化合物被微生物群分解和发酵以产生短链脂肪酸（SCFA）。先前的研究已经确定了SCFAs在控制人体代谢途径中的作用。在这篇综述中，我们评估SCFAs作为代谢调节剂以及它们如何提高运动员的耐力表现。通过观察在动物模型中进行的研究，我们确定了SCFAs下游的几种途径，通过第二信使途径或通过神经元途径直接调节代谢途径，这有助于能量利用。这些途径有助于有效的能量代谢，因此是耐力运动中最大限度地利用底物的关键。未来的研究可能会证明有针对性的饮食干预的有用性，使运动员能够在比赛中最大限度地发挥他们的表现。
The human body is host to a multitude of bacteria, fungi, viruses and other species in the intestine, collectively known as the microbiota. Dietary carbohydrates which bypass digestion and absorption are broken down and fermented by the microbiota to produce short-chain fatty acids (SCFAs). Previous research has established the role of SCFAs in the control of human metabolic pathways. In this review, we evaluate SCFAs as a metabolic regulator and how they might improve endurance performance in athletes. By looking at research conducted in animal models, we identify several pathways downstream of SCFAs, either directly modulating metabolic pathways through second messenger pathways or through neuronal pathways, that contribute to energy utilisation. These pathways contribute to efficient energy metabolism and are thus key to maximising substrate utilisation in endurance exercise. Future research may prove the usefulness of targeted dietary interventions allowing athletes to maximise their performance in competition.