Association between anticonvulsant hypersensitivity syndrome and human herpesvirus 6 reactivation and Hypogammaglobulinemia
Association between anticonvulsant hypersensitivity syndrome and human herpesvirus 6 reactivation and Hypogammaglobulinemia
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DOI：
10.1001/archderm.140.2.183
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发表时间：
2004-02-01
影响因子：
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通讯作者：
Shiohara, T
中科院分区：
文献类型：
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作者：
Kano, Y;Inaoka, M;Shiohara, T
背景：抗惊厥药超敏反应综合征（AHS）是一种危及生命的药物诱导的多器官系统反应。确定的诱发因素是明确需要预测AHS的发病率和结果;注意力最近一直集中在人类疱疹病毒6型（HHV-6）的再激活上。目的：为了确定是否免疫抑制条件，可以让HHV-6再激活可以具体检测到与发病AHS.Design：我们分析了患者与AHS谁在1997-2002年期间接受治疗。两组患者接受抗惊厥药;作为对照。设定：患者：10例AHS患者。主要结果：包括HHV-6在内的各种病毒抗体滴度的血清学检测结果。结果：与对照组相比，AHS患者的血清IgG水平（平均745 mg/dL）和循环B细胞计数（平均88/穆尔）在发病时显著降低（P
Background: Anticonvulsant hypersensitivity syndrome (AHS) is a life-threatening, drug-induced, multiorgan system reaction. The identification of predisposing factors is clearly needed to predict the incidence and outcome of AHS; attention has recently been focused on reactivation of human herpesvirus 6 (HHV-6).Objective: To determine whether immunosuppressive conditions that can allow HHV-6 reactivation could be specifically detected in association with the onset of AHS.Design: We analyzed patients with AHS who were treated during 1997-2002. Two groups of patients receiving anticonvulsants; served as controls. Setting: Department of Dermatology, Kyorin University School of Medicine, Tokyo, Japan.Patients: Ten patients with AHS.Main Outcome Measures: The results of serologic tests for antibody titers for various viruses, including HHV-6,Results: Serum IgG levels (mean, 745 mg/dL) and circulating B-cell counts (mean, 88/muL) in patients with AHS were significantly decreased at onset compared with control groups (P