Efficacy, dosage, and duration of action of branched chain amino Acid therapy for traumatic brain injury.
Efficacy, dosage, and duration of action of branched chain amino Acid therapy for traumatic brain injury.
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DOI：
10.3389/fneur.2015.00073
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发表时间：
2015
影响因子：
3.4
通讯作者：
Cohen AS
中科院分区：
文献类型：
--
作者：
Elkind JA;Lim MM;Johnson BN;Palmer CP;Putnam BJ;Kirschen MP;Cohen AS
Traumatic brain injury (TBI) results in long-lasting cognitive impairments for which there is currently no accepted treatment. A well-established mouse model of mild to moderate TBI, lateral fluid percussion injury (FPI), shows changes in network excitability in the hippocampus including a decrease in net synaptic efficacy in area CA1 and an increase in net synaptic efficacy in dentate gyrus. Previous studies identified a novel therapy consisting of branched chain amino acids (BCAAs), which restored normal mouse hippocampal responses and ameliorated cognitive impairment following FPI. However, the optimal BCAA dose and length of treatment needed to improve cognitive recovery is unknown. In the current study, mice underwent FPI then consumed 100 mM BCAA supplemented water ad libitum for 2, 3, 4, 5, and 10 days. BCAA therapy ameliorated cognitive impairment at 5 and 10 days duration. Neither BCAA supplementation at 50 mM nor BCAAs when dosed 5 days on then 5 days off was sufficient to ameliorate cognitive impairment. These results suggest that brain injury causes alterations in hippocampal function, which underlie and contribute to hippocampal cognitive impairment, which are reversible with at least 5 days of BCAA treatment, and that sustaining this effect is dependent on continuous treatment. Our findings have profound implications for the clinical investigation of TBI therapy.
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影响因子：
16.2
作者：
Hearing M;Kotecki L;Marron Fernandez de Velasco E;Fajardo-Serrano A;Chung HJ;Luján R;Wickman K
通讯作者：
Wickman K
影响因子：
3.3
作者：
Hoskison MM;Moore AN;Hu B;Orsi S;Kobori N;Dash PK
通讯作者：
Dash PK
影响因子：
5.3
作者：
Lee J;Chung C;Ha S;Lee D;Kim DY;Kim H;Kim E
通讯作者：
Kim E
影响因子：
3.5
作者：
Dembrow N;Johnston D
通讯作者：
Johnston D
影响因子：
5.3
作者：
Kalmbach, Brian E.;Chitwood, Raymond A.;Johnston, Daniel
通讯作者：
Johnston, Daniel