A capillary viscometer designed for the characterization of biocompatible ferrofluids
A capillary viscometer designed for the characterization of biocompatible ferrofluids
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专为表征生物相容性铁磁流体而设计的毛细管粘度计
DOI：
10.1016/j.jmmm.2016.03.057
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发表时间：
2016
影响因子：
2.7
通讯作者：
S. Odenbach
中科院分区：
文献类型：
--
作者：
J. Nowak;S. Odenbach
磁性纳米粒子的悬浮液在生物医学研究中越来越受到关注。例如，这些铁磁流体可以利用药物靶向原理或使用人工诱导加热来治疗癌症。为了实现安全应用，必须充分了解铁磁流体的基本特性，包括施加外部磁场时流体的粘度。众所周知，如果施加磁场，铁磁流体的粘度就会上升，其上升取决于剪切速率和磁场强度。在生物相容性铁磁流体的情况下，此类研究被证明相当复杂，因为实验设置应接近实际应用，以允许对预期效果进行合理的预测。因此，设计了一种毛细管粘度计，其提供与血管中的流动相当的流动情况。玻璃毛细管是可更换的，并且可以使用不同的内径。剪切速率的范围已适应人体组织中发现的范围。外部磁场的应用是通过两种不同的线圈设置实现的，一方面覆盖了所需的磁场强度范围，一方面是对颗粒相互作用和由此产生的粘度变化的理论理解，另一方面是潜在生物医学应用所需的值。结果表明，新设计的毛细管粘度计适合测量生物相容性铁磁流体中的磁粘性效应，并且结果似乎与旋转流变仪测量的数据一致。此外，在潜在生物医学应用预期的剪切速率和磁场强度范围内，生物相容性铁磁流体的流动行为发生了强烈变化。
Suspensions of magnetic nanoparticles are receiving a growing interest in biomedical research. These ferrofluids can, e.g., be used for the treatment of cancer, making use of the drug targeting principle or using an artificially induced heating. To enable a safe application the basic properties of the ferrofluids have to be well understood, including the viscosity of the fluids if an external magnetic field is applied. It is well known that the viscosity of ferrofluids rises if a magnetic field is applied, where the rise depends on shear rate and magnetic field strength. In case of biocompatible ferrofluids such investigations proved to be rather complicated as the experimental setup should be close to the actual application to allow justified predictions of the effects which have to be expected. Thus a capillary viscometer, providing a flow situation comparable to the flow in a blood vessel, has been designed. The glass capillary is exchangeable and different inner diameters can be used. The range of the shear rates has been adapted to the range found in the human organism. The application of an external magnetic field is enabled with two different coil setups covering the ranges of magnetic field strengths required on the one hand for a theoretical understanding of particle interaction and resulting changes in viscosity and on the other hand for values necessary for a potential biomedical application.The results show that the newly designed capillary viscometer is suitable to measure the magnetoviscous effect in biocompatible ferrofluids and that the results appear to be consistent with data measured with rotational rheometry. In addition, a strong change of the flow behaviour of a biocompatible ferrofluid was proven for ranges of the shear rate and the magnetic field strength expected for a potential biomedical application.
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DOI：
10.1088/0953-8984/18/38/s17
发表时间：
2006
期刊：
Journal of Physics: Condensed Matter
影响因子：
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作者：
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通讯作者：
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影响因子：
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DOI：
10.1088/0953-8984/20/20/204139
发表时间：
2008
期刊：
Journal of Physics: Condensed Matter
影响因子：
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作者：
L. Pop;S. Odenbach
通讯作者：
S. Odenbach
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影响因子：
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作者：
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通讯作者：
S. Odenbach
影响因子：
2.7
作者：
Linke, J. M.;Odenbach, S.
通讯作者：
Odenbach, S.