Fibrogenesis I. New insights into hepatic stellate cell activation: the simple becomes complex
Fibrogenesis I. New insights into hepatic stellate cell activation: the simple becomes complex
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DOI：
10.1152/ajpgi.2000.279.1.g7
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发表时间：
2000-07-01
影响因子：
4.5
通讯作者：
Friedman, SL
中科院分区：
文献类型：
--
作者：
Eng, FJ;Friedman, SL
肝星状细胞活化是一个复杂的过程。目前存在的问题和争议包括肝星状细胞的起源、膜受体信号传导和转录的调控以及肝损伤消退后细胞的命运。主要的主题已经出现，包括自分泌信号的主导地位和识别反调节刺激，反对激活细胞的关键特征。分析方法的进步，包括蛋白质组学和基因阵列，加上强大的生物信息学，有望彻底改变我们如何看待细胞反应。我们对星状细胞激活的理解可能会从这些进展中受益，揭示了调节细胞行为的模式，这些模式在当前的范式基础上甚至无法想象。
Hepatic stellate cell activation is a complex process. Paradoxes and controversies include the origin(s) of hepatic stellate cells, the regulation of membrane receptor signaling and transcription, and the fate of the cells once liver injury resolves. Major themes have emerged, including the dominance of autocrine signaling and the identification of counterregulatory stimuli that oppose key features of activated cells. Advances in analytical methods including proteomics and gene array, coupled with powerful bioinformatics, promise to revolutionize how we view cellular responses. Our understanding of stellate cell activation is likely to benefit from these advances, unearthing modes of regulating cellular behavior that are not even conceivable on the basis of current paradigms.