Renin release and the refractoriness to acute renal failure of rats recovering from prior renal failure.
Renin release and the refractoriness to acute renal failure of rats recovering from prior renal failure.
复制标题
肾素释放和从既往肾衰竭中恢复的大鼠对急性肾衰竭的难治性。
作者：
J. S. Carvalho;D. Landwehr;D. Oken
在对照大鼠和从先前肌血红蛋白尿性急性肾衰竭恢复的动物（恢复大鼠）中测量响应于快速去除15 ml/kg体重血液或皮下施用500 μ g/kg体重异丙肾上腺素的肾素底物浓度和肾素释放。用于这些测定的血液从长期植入的主动脉导管中抽取，避免了对动物处理和麻醉的需要。恢复期大鼠的基线血浆肾素滴度适度升高，但肾素底物浓度与对照组相同。出血导致两组血压和血浆肾素滴度发生相同的变化。恢复期大鼠注射异丙肾上腺素后，血压下降幅度稍大，血浆肾素浓度升高幅度几乎是对照组大鼠的两倍。因此，恢复期动物对第二次急性肾衰竭的显著抵抗不能归因于受损的肾素释放或血浆肾素底物不足。
Renin substrate concentrations and the release of renin in response to the rapid removal of 15 ml/kg weight blood or subcutaneous administration of 500 microgram/kg body weight isoproterenol were measured in control rats and animals recovering from prior myohemoglobinuric acute renal failure (recovery rats). Blood for these assayas was drawn from chronically implanted aortic catheters, obviating the need for animal handling and anesthesia. Baseline plasma renin titers of recovery rats were modestly elevated but renin substrate concentrations were the same as in controls. Hemorrhage produced equivalent changes in blood pressure and plasma renin titer in the two groups. Isoproternol injection in recovery rats caused a somewhat greater blood pressure fall and almost twice the rise in plasma renin concentration observed in control rats. The marked resistance of recovery animals to a second bout of acute renal failure thus cannot be attributed to impaired renin release or inadequate plasma renin substrate.