Joint Effect of Childhood Abuse and Family History of Major Depressive Disorder on Rates of PTSD in People with Personality Disorders.
Joint Effect of Childhood Abuse and Family History of Major Depressive Disorder on Rates of PTSD in People with Personality Disorders.
复制标题
DOI：
10.1155/2012/350461
复制
发表时间：
2012
影响因子：
--
通讯作者：
Siever LJ
中科院分区：
文献类型：
--
作者：
Flory JD;Yehuda R;Passarelli V;Siever LJ
Objective.童年期虐待和家族性精神病理学都导致成年后患创伤后应激障碍（PTSD）的风险增加。虽然精神病理学家族史传统上被视为遗传易感性的代表，但这种病理学也可能导致儿童的压力环境。法进行分析，以评估儿童期虐待和抑郁症（MDD）的家族史的PTSD和MDD的诊断在一个样本的225名成年人与DSM-IV轴II障碍的联合作用。结果结果显示，在儿童期虐待和MDD家族史的存在下，PTSD的发生率几乎是没有这两个因素的六倍（OR = 5.89，P = 0.001）。相比之下，两种因素同时存在的MDD发生率与参考组的近3倍风险相关（OR = 2.75，P = .01）。结论.这项观察性研究的结果有助于人们越来越多地了解PTSD发展的诱发因素，并表明MDD家族史和儿童期虐待对PTSD的联合影响大于单独的因素。
Objective. Childhood maltreatment and familial psychopathology both lead to an increased risk of the development of posttraumatic stress disorder (PTSD) in adulthood. While family history of psychopathology has traditionally been viewed as a proxy for genetic predisposition, such pathology can also contribute to a stress-laden environment for the child. Method. Analyses were conducted to evaluate the joint effect of childhood abuse and a family history of major depressive disorder (MDD) on diagnoses of PTSD and MDD in a sample of 225 adults with DSM-IV Axis II disorders. Results. Results showed that the rate of PTSD in the presence of both childhood abuse and MDD family history was almost six-fold (OR = 5.89, P = .001) higher relative to the absence of both factors. In contrast, the rate of MDD in the presence of both factors was associated with a nearly three-fold risk relative to the reference group (OR = 2.75, P = .01). Conclusions. The results from this observational study contribute to a growing understanding of predisposing factors for the development of PTSD and suggest that joint effects of family history of MDD and childhood abuse on PTSD are greater than either factor alone.