Symptoms of anxiety and depression in the course of cognitive decline
Symptoms of anxiety and depression in the course of cognitive decline
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DOI：
10.1159/000107083
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发表时间：
2007-01-01
影响因子：
2.4
通讯作者：
Beekman, A. T. F.
中科院分区：
文献类型：
--
作者：
Bierman, E. J. M.;Comijs, H. C.;Beekman, A. T. F.
背景/目标：焦虑和抑郁在认知功能下降和阿尔茨海默病（AD）患者中很常见，识别和治疗这些症状可以改善他们的生活质量。本研究调查了认知功能下降不同阶段的焦虑和抑郁。研究方法：样本包括五组处于不同认知衰退阶段的老年人;四组来自基于社区的样本（阿姆斯特丹纵向老龄化研究），一组被诊断为AD的老年人。进行方差分析，以调查组间焦虑和抑郁的严重程度和患病率的差异，以及共病的焦虑和抑郁症状。结果如下：焦虑、焦虑和抑郁症状共病以及抑郁症状的患病率遵循以下模式：随着认知能力下降，患病率增加;当认知功能严重受损时，患病率降低。AD患者报告的焦虑症状最少。结论：我们发现，焦虑症状，抑郁症状和共病的焦虑和抑郁症状的患病率似乎在认知功能下降的早期阶段增加，并随着认知功能的进一步下降而减少。诊断为AD的老年人报告的焦虑程度较低，这可能是由于缺乏AD引起的洞察力。
Background/ Aims: Anxiety and depression are common in patients with cognitive decline and Alzheimer's disease ( AD), and recognition and treatment of these symptoms can improve their quality of life. The present study investigates anxiety and depression in different phases of cognitive decline. Methods: The sample consisted of five groups of elderly people in different phases of cognitive decline; four from a community-based sample ( Longitudinal Aging Study Amsterdam), and one group of elderly people diagnosed with AD. ANOVAs were performed to investigate group differences in the severity and prevalence of anxiety and depression, and comorbid anxiety and depressive symptoms. Results: The prevalence rates of anxiety, comorbid anxiety and depressive symptoms and depressive symptoms follow a pattern of an increasing prevalence as cognitive performance declines and a decrease in the prevalence when cognitive functioning is severely impaired. AD patients report fewest anxiety symptoms. Conclusion: We found that the prevalence of anxiety symptoms, depressive symptoms and comorbid anxiety and depressive symptoms seems to increase in the early phase of cognitive decline, and decreases as cognitive functioning further declines. Elderly diagnosed with AD report less anxiety as expected, probably due to lack of insight caused by AD.