Current Progress on Host Antiviral Factor IFITMs.
Current Progress on Host Antiviral Factor IFITMs.
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宿主抗病毒因子 IFITM 的最新进展。
DOI：
10.3389/fimmu.2020.543444
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发表时间：
2020
影响因子：
7.3
通讯作者：
Li C
中科院分区：
文献类型：
--
作者：
Ren L;Du S;Xu W;Li T;Wu S;Jin N;Li C
宿主抗病毒因子干扰素诱导的跨膜蛋白（IFITMs）是一类由干扰素诱导的小分子跨膜蛋白。其广谱的抗病毒活性和独特的抑制病毒入侵的能力使其成为近年来抗病毒研究的热点分子。自1996年首次证明其天然抗病毒感染能力以来，IFITMs被报道限制多种病毒感染，包括一些严重危害人类健康和社会稳定的主要病原体，如甲型流感、Ebol、严重急性呼吸道综合征、艾滋病和寨卡病毒等。研究表明，IFITMs主要在病毒进入时发挥抗病毒活性，特异性干扰包膜和内体膜的融合或形成融合微孔以阻断病毒进入细胞质。但其具体机制尚不清楚。本文主要综述了IFITMs的结构、进化、功能和作用机制等方面的研究进展，为阐明IFITMs与病毒相互作用的分子机制以及基于IFITMs的抗病毒新药研发提供理论依据。
Host antiviral factor interferon-induced transmembrane proteins (IFITMs) are a kind of small-molecule transmembrane proteins induced by interferon. Their broad-spectrum antiviral activity and unique ability to inhibit viral invasion have made them a hot molecule in antiviral research in recent years. Since the first demonstration of their natural ability to resist viral infection in 1996, IFITMs have been reported to limit a variety of viral infections, including some major pathogens that seriously endanger human health and social stability, such as influenza A, Ebol, severe acute respiratory syndrome, AIDS, and Zika viruses, etc. Studies show that IFITMs mainly exert antiviral activity during virus entry, specifically interfering with the fusion of the envelope and the endosome membrane or forming fusion micropores to block the virus from entering the cytoplasm. However, their specific mechanism is still unclear. This article mainly reviews the research progress in the structure, evolution, function, and mechanism of IFITMs, which may provide a theoretical basis for clarifying the molecular mechanism of interaction between the molecules and viruses and the research and development of new antiviral drugs based on IFITMs.
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