High expression of IRE1 in lung adenocarcinoma is associated with a lower rate of recurrence.
High expression of IRE1 in lung adenocarcinoma is associated with a lower rate of recurrence.
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DOI：
10.1093/jjco/hyx031
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发表时间：
2017-06-01
影响因子：
2.4
通讯作者：
Takai D
中科院分区：
文献类型：
--
作者：
Sakatani T;Maemura K;Hiyama N;Amano Y;Watanabe K;Kage H;Fukayama M;Nakajima J;Yatomi Y;Nagase T;Takai D
内质网应激相关基因的高表达在肺腺癌的低分期和微小血管浸润患者中观察到。肌醇需要激酶1的高表达是无复发生存的独立预测因子。最近的报道表明，内质网应激与癌症有关。然而，内质网应激对肺癌预后的影响尚不清楚。因此，在本研究中，我们试图揭示内质网应激相关基因（内质网氧化还原酶1 L，蛋白激酶RNA样内质网激酶，转录激活因子6和肌醇需要激酶1）的表达与肺腺癌的结果之间的关系。126例手术切除的肺腺癌患者进行了内质网应激相关的mRNA表达定量RT-PCR分析。分析所有研究患者的以下参数：年龄、性别、疾病分期、吸烟状态、淋巴结浸润（ly）、血管浸润（v）和EGFR突变状态。我们根据内质网应激相关基因的表达水平将患者分为高表达组和低表达组。内质网应激相关基因的高表达在肺腺癌的低分期和微小血管浸润患者中观察到。Kaplan-Meier分析显示高表达组和低表达组的无复发生存期和总生存期差异有统计学意义。肌醇依赖激酶1高表达是肺腺癌患者无复发生存的独立预测因子（风险比，0.396; 95%可信区间，0.188-0.834; P = 0.015）。肌醇需要激酶1可能是预测手术切除肺腺癌患者复发的有用生物标志物。
High expression of endoplasmic reticulum stress-related genes was observed in patients with lower stages of lung adenocarcinoma and minimal vascular invasion. High inositol-requiring kinase 1 expression was an independent predictor of recurrence-free survival. Recent reports have shown that endoplasmic reticulum stress is associated with cancer. However, the impacts of endoplasmic reticulum stress on the prognosis of lung cancer are unknown. Therefore, in this study, we sought to reveal the relationship between the expression of endoplasmic reticulum stress-related genes (endoplasmic reticulum oxidoreductase 1L, protein kinase RNA-like endoplasmic reticulum kinase, activating transcription factor 6 and inositol-requiring kinase 1) and the outcome of lung adenocarcinoma. One hundred and twenty-six patients with surgically resected lung adenocarcinomas were subjected to an endoplasmic reticulum stress-related mRNA expression analysis using quantitative RT-PCR. The following parameters were analyzed for all the study patients: age, sex, disease stage, smoking status, lymph node invasion (ly), vascular invasion (v) and EGFR mutation status. We assigned patients to either a high-expression group or a low-expression group according to the expression levels of endoplasmic reticulum stress-related genes. High expressions of endoplasmic reticulum stress-related genes were observed in patients with lower stages of lung adenocarcinoma and minimal vascular invasion. A Kaplan–Meier analysis showed significant differences in recurrence-free survival and overall survival between high-expression group and low-expression group. High inositol-requiring kinase 1 expression was an independent predictor of recurrence-free survival among patients with lung adenocarcinoma (hazard ratio, 0.396; 95% confidence interval, 0.188–0.834; P = 0.015). Inositol-requiring kinase 1 may be a useful biomarker to predict recurrence in surgically resected lung adenocarcinoma patients.