Alignment interactions drive structural transitions in biological tissues
Alignment interactions drive structural transitions in biological tissues
复制标题
排列相互作用驱动生物组织的结构转变
DOI：
10.1103/physreve.104.044606
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发表时间：
2021
影响因子：
2.4
通讯作者：
Ruocco, Giancarlo
中科院分区：
文献类型：
--
作者：
Paoluzzi, Matteo;Angelani, Luca;Gosti, Giorgio;Marchetti, M. Cristina;Pagonabarraga, Ignacio;Ruocco, Giancarlo
实验证据表明，细胞形状和细胞运动之间存在反馈关系。这种反馈如何影响致密细胞单层的集体行为仍然是一个悬而未决的问题。在生物组织模型中，我们研究了倾向于将细胞爬行方向与细胞伸长对齐的反馈的效果。我们发现，取向相互作用促进了流体相中的向列型，这些向列型最终经历了非平衡相变为准六方固体。同时，高度不对称的细胞不会经历液到固的转变，无论对齐耦合的任何值。在这种情况下，细胞中心的动态和形状波动表现出玻璃系统的典型特征。
Experimental evidence shows that there is a feedback between cell shape and cell motion. How this feedback impacts the collective behavior of dense cell monolayers remains an open question. We investigate the effect of a feedback that tends to align the cell crawling direction with cell elongation in a biological tissue model. We find that the alignment interaction promotes nematic patterns in the fluid phase that eventually undergo a nonequilibrium phase transition into a quasihexagonal solid. Meanwhile, highly asymmetric cells do not undergo the liquid-to-solid transition for any value of the alignment coupling. In this regime, the dynamics of cell centers and shape fluctuation show features typical of glassy systems.