Repeated exposure to systemic inflammation and risk of new depressive symptoms among older adults.
Repeated exposure to systemic inflammation and risk of new depressive symptoms among older adults.
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DOI：
10.1038/tp.2017.155
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发表时间：
2017-08-15
影响因子：
6.8
通讯作者：
Carvalho LA
中科院分区：
文献类型：
--
作者：
Bell JA;Kivimäki M;Bullmore ET;Steptoe A;MRC ImmunoPsychiatry Consortium;Carvalho LA
全身炎症作为未来抑郁症的危险因素的证据是不一致的，可能是由于缺乏对持续暴露的考虑。我们使用来自50岁或50岁以上成年人人群样本的前瞻性数据（英国老龄化纵向研究），研究了多次发炎是否会增加新的抑郁症状的风险。根据流行病学研究中心的八项抑郁量表，分析了2004/05和2008/09年度八项抑郁症状中少于四项的参与者。在2008/09年至2012/13年期间，检查了在相同的初始评估中C反应蛋白≥ 3 mg l−1的次数（1 vs 0次，2 vs 0次）与抑郁症状变化的关系，以及2012/13年发生抑郁症（8种症状中有4种以上）的几率。在多变量调整回归模型中（n=2068），1次与0次发炎的参与者没有表现出抑郁症状的增加，也没有表现出发展抑郁症的几率增加; 2次与0次发炎的患者显示症状增加0.10（95%置信区间（CI）=-0.07，0.28），几率增加1.60（95% CI=1.00，2.55）倍。在进一步的分析中，2 vs 0次炎症与女性抑郁症状发生几率增加相关（比值比（OR）=2.75，95% CI=1.53，4.95），但与男性无关（OR=0.70，95% CI=0.29，1.68）; P-性别相互作用=0.035。在这项老年人队列研究中，反复但非短暂暴露于全身炎症与女性未来抑郁症状的风险增加相关;这一亚组发现需要确认有效性。
Evidence on systemic inflammation as a risk factor for future depression is inconsistent, possibly due to a lack of regard for persistency of exposure. We examined whether being inflamed on multiple occasions increases risk of new depressive symptoms using prospective data from a population-based sample of adults aged 50 years or older (the English Longitudinal Study of Ageing). Participants with less than four of eight depressive symptoms in 2004/05 and 2008/09 based on the Eight-item Centre for Epidemiologic Studies Depression scale were analysed. The number of occasions with C-reactive protein ⩾3 mg l−1 over the same initial assessments (1 vs 0 occasion, and 2 vs 0 occasions) was examined in relation to change in depressive symptoms between 2008/09 and 2012/13 and odds of developing depressive symptomology (having more than or equal to four of eight symptoms) in 2012/13. In multivariable-adjusted regression models (n=2068), participants who were inflamed on 1 vs 0 occasion showed no increase in depressive symptoms nor raised odds of developing depressive symptomology; those inflamed on 2 vs 0 occasions showed a 0.10 (95% confidence intervals (CIs)=−0.07, 0.28) symptom increase and 1.60 (95% CI=1.00, 2.55) times higher odds. In further analyses, 2 vs 0 occasions of inflammation were associated with increased odds of developing depressive symptoms among women (odds ratio (OR)=2.75, 95% CI=1.53, 4.95), but not among men (OR=0.70, 95% CI=0.29, 1.68); P-for-sex interaction=0.035. In this cohort study of older adults, repeated but not transient exposure to systemic inflammation was associated with increased risk of future depressive symptoms among women; this subgroup finding requires confirmation of validity.
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炎症激活与忧郁症主要抑郁症的住院患者的单核细胞中糖皮质激素受体α/β表达比降低有关。
影响因子：
6.8
作者：
Carvalho LA;Bergink V;Sumaski L;Wijkhuijs J;Hoogendijk WJ;Birkenhager TK;Drexhage HA
通讯作者：
Drexhage HA
影响因子：
25.8
作者：
Khandaker GM;Pearson RM;Zammit S;Lewis G;Jones PB
通讯作者：
Jones PB
DOI：
10.1016/j.bbi.2015.06.001
发表时间：
2015-10
期刊：
Brain, behavior, and immunity
影响因子：
--
作者：
Haapakoski R;Mathieu J;Ebmeier KP;Alenius H;Kivimäki M
通讯作者：
Kivimäki M
影响因子：
--
作者：
Irwin, M;Artin, KHH;Oxman, MN
通讯作者：
Oxman, MN
影响因子：
--
作者：
Lyness, JM;Noel, TK;Caine, ED
通讯作者：
Caine, ED