Sending ROS on a Bullet Train
Sending ROS on a Bullet Train
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DOI：
10.1126/scisignal.290pe60
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发表时间：
2009-09
影响因子：
7.3
通讯作者：
H. Wong;K. Shimamoto
中科院分区：
文献类型：
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作者：
H. Wong;K. Shimamoto
过氧化氢是由RBOHD在拟南芥中产生的一种自动繁殖的快速系统胁迫信号。植物必须应对生物胁迫，如疾病、机械伤害和食草性胁迫，以及非生物胁迫，如热、冷和盐。针对这些威胁的早期预警系统将防止或减少植物遭受的损害。这样的预警系统应能使信号迅速产生并远距离发送。植物系统信号的研究一直是一个重大的科学挑战。活性氧（ROS）是已提出的系统信号之一。现在，令人兴奋的发现是，系统ROS信号是由NADPH（烟酰胺腺嘌呤二核苷酸磷酸，还原形式）氧化酶介导的，这为理解启动和传播快速系统信号的分子机制打开了大门。
Hydrogen peroxide is an auto-propagating, rapid systemic stress signal generated by RBOHD in Arabidopsis. Plants have to contend with biotic stress, such as disease, mechanical wounding, and herbivory, as well as abiotic stress, such as heat, cold, and salinity. An early warning system for these threats would prevent or reduce the damage suffered by plants. Such a warning system should allow the signal to be rapidly generated and sent over long distances. The study of systemic signaling in plants has been a major scientific challenge. Reactive oxygen species (ROS) are among the systemic signals that have been proposed. Now, the exciting discovery that systemic ROS signaling is mediated by an NADPH (nicotinamide adenine dinucleotide phosphate, reduced form) oxidase opens the door to understanding the molecular mechanisms that initiate and propagate a rapid systemic signal.