Comparison of 2-amino-[3-11C]isobutyric acid and 2-deoxy-2-[18F]fluoro-D-glucose in nude mice with xenografted tumors and acute inflammation
Comparison of 2-amino-[3-11C]isobutyric acid and 2-deoxy-2-[18F]fluoro-D-glucose in nude mice with xenografted tumors and acute inflammation
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2-氨基-[3-11C]异丁酸和2-脱氧-2-[18F]氟-D-葡萄糖在裸鼠异种移植肿瘤和急性炎症中的比较
DOI：
10.1097/mnm.0b013e328356efb0
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发表时间：
2012
期刊：
影响因子：
--
通讯作者：
Saga T
中科院分区：
文献类型：
--
作者：
Tsuji AB;Kato K;Sugyo A;Okada M;Sudo H;Yoshida C;Wakizaka H;Zhang MR;Saga T
Objective2-Deoxy-2-[18 F] fluoro-D-glucose ([18 F] FDG) accumulates in tumors and also during active inflammation, including therapy-related inflammation. Additional PET tracers that are less avid to inflammation could be useful in differentiating cancer from inflammation and could complement the limitation of [18 F] FDG-PET. 2-Amino-[3-11 C] isobutyric acid ([3-11 C] AIB) is a potential PET tracer for this purpose. We compared [3-11 C] AIB and [18 F] FDG uptakes in tumors and acute inflammation in a mouse model.MethodsAcute inflammatory lesions were induced in the hind legs of tumor-bearing mice by intramuscular injection of turpentine, and we conducted biodistribution and dynamic PET studies on [3-11 C] AIB and [18 F] FDG.Results[3-11 C] AIB tumor uptake increased with time and was statistically significantly higher than [18 F] FDG uptake. In inflamed muscles,[3-11 C] AIB uptake was statistically significantly lower than [18 F] FDG uptake, and the tumor-to-inflammation ratio for [3-11 C] AIB was statistically significantly higher than that for [18 F] FDG.Conclusion[3-11 C] AIB accumulates more selectively in tumor tissue than does [18 F] FDG and thus has the potential of discriminating between tumors and inflammatory lesions better and of complementing the limitation of [18 F] FDG.
