Characterization of autonomic receptors in neonatal urinary tract smooth muscle.
Characterization of autonomic receptors in neonatal urinary tract smooth muscle.
复制标题
新生儿尿路平滑肌自主神经受体的特征。
DOI：
10.1159/000457575
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发表时间：
1989
期刊：
影响因子：
--
通讯作者：
Weiss,RM
中科院分区：
文献类型：
--
作者：
Latifpour,J;Morita,T;O'Hollaren,B;Kondo,S;Weiss,RM
1日龄家兔尿路平滑肌各部位存在大量α -2-（用[3H]育himine标记）比α -1-（用[3H]prazosin标记）肾上腺素能受体，但α -1受体在功能上对激动剂的反应比α -2受体更灵敏。与成年兔的研究结果不同，新生儿膀胱穹窿在功能上比新生儿膀胱基底对α -肾上腺素能激动剂更敏感。不同尿路平滑肌中β -肾上腺素能受体密度（用[3H]二氢阿普萘洛尔标记）的等级顺序与异丙肾上腺素的松弛反应程度相关。新生儿尿路中存在大量功能性毒蕈碱受体（标记为[3H]喹啉苄基）。这些数据表明新生儿尿路平滑肌中存在功能性自主神经受体。
In the 1-day-old rabbit there are a large number of alpha-2- (labeled with [3H]yohimbine)than alpha-1- (labeled with [3H]prazosin) adrenergic receptors in the various parts of urinary tract smooth muscle, but the alpha-1 receptors are functionally more responsive to agonists than are the alpha-2 receptors. Unlike the findings in the adult rabbit, the neonatal bladder dome is functionally more sensitive to alpha-adrenergic agonists than the neonatal bladder base. The rank order of beta-adrenergic receptor densities (labeled with [3H]dihydroalprenolol)in various urinary tract smooth muscles correlates with the magnitude of the relaxant response to isoproterenol. There is a high number of functional muscarinic receptors(labeled with [3H]quinuclidinyl benzylate) in the neonatal urinary tract. The data demonstrate the existence of functional autonomic receptors in neonatal urinary tract smooth muscle.