Role of renal TRP channels in physiology and pathology.
Role of renal TRP channels in physiology and pathology.
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肾脏TRP通道在生理和病理学中的作用。
DOI：
10.1007/s00281-015-0527-z
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发表时间：
2016-05
影响因子：
9
通讯作者：
Pochynyuk O
中科院分区：
文献类型：
--
作者：
Tomilin V;Mamenko M;Zaika O;Pochynyuk O
肾脏通过调节水和电解质平衡、调节细胞外液容量、血浆渗透压和血压，对维持全身稳态起着至关重要的作用。肾功能受许多全身内分泌和局部机械刺激的调节。肾脏拥有一个由膜受体、转运体和离子通道组成的复杂网络，可以以一种综合的方式对这些广泛的信号输入做出反应。瞬时受体电位（TRP）通道家族成员具有不同的激活模式、不同的渗透特性和整合多种下游信号的能力，是肾脏功能的关键分子决定因素。本文综述了TRP通道在健康哺乳动物肾脏中的作用的实验数据，并讨论了它们在肾脏病理中的作用。
Kidneys critically contribute to the maintenance of whole-body homeostasis by governing water and electrolyte balance, regulating extracellular fluid volume, plasma osmolality and blood pressure. Renal function is regulated by numerous systemic endocrine and local mechanical stimuli. Kidneys possess a complex network of membrane receptors, transporters and ion channels which allows responding to this wide array of signaling inputs in an integrative manner. Transient receptor potential (TRP) channel family members with diverse modes of activation, varied permeation properties and capability to integrate multiple downstream signals are pivotal molecular determinants of renal function all along the nephron. This review summarizes experimental data on the role of TRP channels in a healthy mammalian kidney and discusses their involvement in renal pathologies.