Subnormal alpha-2-adrenoceptor-mediated sedation during 6 months of sobriety in male type 1 alcohol-dependent subjects
Subnormal alpha-2-adrenoceptor-mediated sedation during 6 months of sobriety in male type 1 alcohol-dependent subjects
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DOI：
10.1093/alcalc/agg086
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发表时间：
2003-07-01
影响因子：
2.8
通讯作者：
Balldin, J
中科院分区：
文献类型：
--
作者：
Berggren, U;Berglund, K;Balldin, J
目的：在本研究中，研究了8名男性酒精依赖受试者戒酒6个月后的α(2)肾上腺素能受体功能。方法：受试者在饮酒后第1天、第7天、结束后第2个月和第6个月进行重复可乐定(Clon，2g/kg体重静脉注射)激发试验。在激发试验中对克隆诱导的镇静进行评级。在所有挑战测试之前，都会自我报告精神健康状况。6名男性健康对照组每隔1周进行3次挑战测试。结果：与对照组三次激发试验的平均值相比，酒精依赖受试者在克隆后的所有时间点的镇静作用显著低于对照组。6个月时，心理幸福感的三个维度与克隆性镇静评分呈负相关。结论：克隆性镇静至少6个月后，α(2)-肾上腺素能受体功能低于正常。这种不正常的受体功能是预先存在的，可能是由基因决定的，还是长期饮酒的结果，必须进一步研究，酒精依赖患者在戒酒时间较长的情况下，这种受体状态也应该得到进一步研究。
Aims: In the present study, alpha(2)-adrenoceptor function was investigated over 6 months of sobriety in eight male alcohol-dependent subjects. Methods: Subjects were investigated with repeated clonidine (CLON, 2 mug/kg body weight intravenously) challenge tests at days 1 and 7, and months 2 and 6 after the end of a period of heavy alcohol intake. CLON-induced sedation was rated at challenge tests. Mental well-being was self-reported before all challenge tests. Three challenge tests were performed at 1-week intervals in six male healthy controls. Results: Sedation was significantly lower after CLON at all time-points for the challenge tests in alcohol-dependent subjects compared with mean values for three challenge tests in controls. Three dimensions of mental well-being were negatively correlated with scores of CLON-induced sedation at month 6. Conclusions: alpha(2)-Adrenoceptor function is subnormal, as assessed by CLON-induced sedation, for at least 6 months after termination of alcohol intake. Whether this subnormal receptor function is pre-existing and possibly genetically determined or is a consequence of long-term alcohol intake must be further investigated, as should this receptor status in alcohol-dependent subjects with longer time-periods of sobriety.