Phosphatases in the cellular response to DNA damage.
Phosphatases in the cellular response to DNA damage.
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DOI：
10.1186/1478-811x-8-27
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发表时间：
2010-09-22
期刊：
影响因子：
--
通讯作者：
Monteiro AN
中科院分区：
文献类型：
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作者：
Freeman AK;Monteiro AN
在过去的15年中，在描述细胞对DNA损伤的反应方面取得了快速进展。DNA损伤反应网络由大量具有不同功能的蛋白质组成，这些蛋白质检测DNA损伤的存在并发出信号，以协调DNA修复与各种细胞过程，特别是细胞周期进程。这种信号从染色质模板辐射，主要由磷酸化事件驱动，主要是丝氨酸和苏氨酸残基。虽然我们已经积累了关于激酶及其底物的详细信息，但我们对磷酸酶在DNA损伤反应中的作用的理解仍然是初步的。鉴定磷酸酶及其调节将有助于获得DNA损伤反应动力学的全貌。在这里，我们给出了哺乳动物细胞中的DNA损伤反应的概述，然后审查不同的磷酸酶的作用的数据，并讨论它们的生物相关性。
In the last fifteen years, rapid progress has been made in delineating the cellular response to DNA damage. The DNA damage response network is composed of a large number of proteins with different functions that detect and signal the presence of DNA damage in order to coordinate DNA repair with a variety of cellular processes, notably cell cycle progression. This signal, which radiates from the chromatin template, is driven primarily by phosphorylation events, mainly on serine and threonine residues. While we have accumulated detailed information about kinases and their substrates our understanding of the role of phosphatases in the DNA damage response is still preliminary. Identifying the phosphatases and their regulation will be instrumental to obtain a complete picture of the dynamics of the DNA damage response. Here we give an overview of the DNA damage response in mammalian cells and then review the data on the role of different phosphatases and discuss their biological relevance.