Drug testing in biological samples vs. maternal surveys for the detection of substance use during whole pregnancy
Drug testing in biological samples vs. maternal surveys for the detection of substance use during whole pregnancy
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DOI：
10.1080/10550887.2020.1831137
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发表时间：
2020-10-13
影响因子：
2.3
通讯作者：
Fernandez-Lorenzo, Jose Ramon
中科院分区：
文献类型：
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作者：
Gonzalez-Colmenero, Eva;Concheiro-Guisan, Ana;Fernandez-Lorenzo, Jose Ramon
背景 怀孕期间尼古丁、乙醇和药物使用的早期诊断对于提供充分的护理至关重要。目前的筛查程序在可靠性和检测窗口短方面存在局限性。目的 调查妊娠期间物质使用的患病率并确定物质使用的生物标志物以及物质使用的变化。将不同类型生物样本（母体毛发、胎便、胎盘、脐带）的药物检测结果与自我报告的数据进行比较。参与者和设置 使用孕妇及其新生儿的数据进行前瞻性队列研究。方法收集出生时的生物基质并通过液相色谱串联质谱法进行分析。提供了一份纸质调查以确定物质使用习惯。结果共纳入 867 对母婴。根据对生物样本的分析，29.1%的病例对一种或多种物质呈阳性（13.6%尼古丁、8.4%乙醇、8.3%可卡因、6.4%大麻、5.7%阿片类药物）。吸毒母亲的概况是一位单身女性，
Background Early diagnosis of nicotine, ethanol and drug use during pregnancy is critical in order to provide adequate care. Current screening procedures show limitations in terms of reliability and short windows of detection. Objectives To investigate the prevalence and identify biomarkers of substance use and changes in substance use during pregnancy. To compare drug testing results in different types of biological samples (maternal hair, meconium, placenta, umbilical-cord) with self-reported data. Participants and setting Prospective cohort study using data from pregnant women and their newborns. Methods Biological matrices were collected at birth and analyzed by liquid chromatography tandem mass spectrometry. A paper survey was provided to determine substance use habits. Results 867 mother-newborn pairs were included. According to the analysis of biological samples, 29.1% cases were positive for one or more substances (13.6% nicotine, 8.4% ethanol, 8.3% cocaine, 6.4% cannabis, 5.7% opioids). The profile of the substance-using mother was a single woman,