Modelling of radiation damage by 125I on a nucleosome.
Modelling of radiation damage by 125I on a nucleosome.
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125I 对核小体的辐射损伤建模。
DOI：
10.1080/09553009414551441
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发表时间：
1994
影响因子：
2.6
通讯作者：
M. Terrissol
中科院分区：
文献类型：
--
作者：
M. Terrissol
对生物介质中电离辐射的早期物理相互作用的研究已经从水圆柱或球体发展到基于每个原子的空间坐标的代表核小体DNA的结构化体积。在物理化学和化学阶段，DNA的模型已经从不活跃的几何对象发展到DNA与自由基物种反应的积极参与。在本文中，数据的建模与核小体DNA的低能电子的相互作用。核小体核心单元已被建模为146-bp螺旋DNA，包含> 9000个原子，缠绕在核心单元周围。已通过将核小体靶置于液态水环境中并引入一些用于诱导链断裂的假设来获得低能电子的链断裂产率。125 I衰变诱导SSB和DSB的计算结果与实验数据一致，证实了该核小体模型的可验证性以及电离辐射相互作用的能量沉积和链断裂假设的特征。
Studies of early physical interactions of ionizing radiation in biological medium have evolved from water cylinders or spheres to structured volumes representing nucleosomal DNA, based on spatial co-ordinates for each individual atom. Regarding the physico-chemical and chemical stages, the models of DNA have evolved from inactive geometrical objects to active participation of DNA in the reactions with the radical species. In this paper data are presented on the modelling of the interaction of low energy electrons with nucleosomal DNA. The nucleosome core unit has been modelled as a 146-bp helical DNA, containing > 9000 atoms, wound around the core unit. The yields of strand breaks for low energy electrons has been obtained by placing the nucleosome target in a liquid water environment and introducing a number of assumptions for the induction of strand breaks. The calculated results for the induction of ssb and dsb by 125I decays agree with experimental data, confirming the plausibility of this nucleosome model as well as the characterization of the interaction of ionizing radiation in terms of the energy deposition and the assumptions made for the strand breaks.
掺入的放射性核素的衰变在人类二倍体细胞中引起 DNA 损伤。
影响因子：
11.2
作者：
LeMotte,PK;Little,JB
通讯作者：
Little,JB