Clinical evaluation and hepatic laboratory assessment in individuals with congestive heart failure
Clinical evaluation and hepatic laboratory assessment in individuals with congestive heart failure
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DOI：
10.1590/s0066-782x2007000500015
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发表时间：
2007-05-01
影响因子：
2.6
通讯作者：
Bachur, Luiz Felipe
中科院分区：
文献类型：
--
作者：
Vasconcelos, Luiz Antônio Brito Arruda;Almeida, Eros Antônio de;Bachur, Luiz Felipe
目的：验证每个心力衰竭 (NF) 功能类别患者的临床变化，特别是肝脏实验室变化。方法：2002 年在三级医院收治的 50 名患者的临床和实验室数据 - 丙氨酸转氨酶 (ALT)、天冬氨酸转氨酶 (AST)、碱性磷酸酶 (AP)、γ-谷氨酰转肽酶 (GGT)、胆红素和凝血图通过横断面研究对心力衰竭的诊断进行了研究。根据心力衰竭类别将患者分开，并对他们的数据进行统计比较。排除任何病因的肝病患者。结果：对平均转氨酶值的分析显示，仅 IV 类患者的平均转氨酶值显着增加。另一方面，碱性磷酸酶和 GGT 随心力衰竭分级逐渐升高。结论：心力衰竭的特点是实验室改变的进行性胆汁淤积谱，而转氨酶值仅在晚期 HE 中升高。了解这些改变至关重要，以避免对心力衰竭患者进行不必要的肝脏检查。
Objectives: To verify the clinical alterations and, in particular, hepatic laboratory alterations in patients in each of the heart failure (NF) functional classes.Methods: The clinical and laboratory data - alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (AP), gamma-glutamyl transpeptidase (GGT), bilirubin and coagulogram - of 50 patients admitted in 2002 to a tertiary hospital with the diagnosis of heart failure were researched by means of a cross sectional study. The patients were separated in accordance with their HF class and their data were compared statistically. Patients with hepatopathy of any etiology were excluded.Results: Analysis of the mean transaminase values revealed a significant increase only for the Class IV patients. On the other hand, alkaline phosphatase and GGT presented a progressive increase in accordance with the HF class.Conclusion: HF is characterized by a progressive cholestatic profile of laboratory alterations, while transaminase values are only elevated in advanced HE It is of utmost importance to understand these alterations in order to avoid unnecessary hepatic investigations in individuals with heart failure.