Cell-Sized Liposomes and Droplets: Real-World Modeling of Living Cells
Cell-Sized Liposomes and Droplets: Real-World Modeling of Living Cells
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DOI：
10.3390/ma5112292
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发表时间：
2012-11-13
期刊：
影响因子：
3.4
通讯作者：
Yoshikawa K
中科院分区：
文献类型：
--
作者：
Hamada T;Yoshikawa K
关于细胞大小的囊泡（例如具有脂质双层的脂质体和被脂质单层覆盖的油包水滴）的研究的最新进展旨在实现活细胞的真实世界建模。膜边界的区隔对于生命系统的组织至关重要。由于微约束中相对较大的表面/体积比，膜界面影响与生物功能相关的现象。在本文中，我们主要关注以下主题：（i）有限空间内生物聚合物的构象转变； (ii) 膜表面的分子缔合； (iii) 远程控制细胞大小的膜形态。
Recent developments in studies concerning cell-sized vesicles, such as liposomes with a lipid bilayer and water-in-oil droplets covered by a lipid monolayer, aim to realize the real-world modeling of living cells. Compartmentalization with a membrane boundary is essential for the organization of living systems. Due to the relatively large surface/volume ratio in microconfinement, the membrane interface influences phenomena related to biological functions. In this article, we mainly focus on the following subjects: (i) conformational transition of biopolymers in a confined space; (ii) molecular association on the membrane surface; and (iii) remote control of cell-sized membrane morphology.