A primer on ankyrin repeat function in TRP channels and beyond
A primer on ankyrin repeat function in TRP channels and beyond
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DOI：
10.1039/b801481g
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发表时间：
2008-01-01
影响因子：
--
通讯作者：
Gaudet, Rachelle
中科院分区：
文献类型：
--
作者：
Gaudet, Rachelle
瞬态受体电位（TRP）通道作为多种感官和环境信号的重要受体和转导器正迅速引起人们的关注。该领域的最新进展为许多TRP通道的n端胞质结构域中存在的锚蛋白重复基序的结构和功能提供了新的见解。本重点讨论的主题包括典型锚蛋白重复序列的结构特征，这些重复序列在细胞中发挥功能的新线索，以及如何将这些信息应用于TRP通道和其他含有锚蛋白重复序列的蛋白质的进一步实验。
Transient receptor potential (TRP) channels are rapidly gaining attention as important receptors and transducers of diverse sensory and environmental cues. Recent progress in the field has provided new insights into the structure and function of the ankyrin repeat motifs present in the N-terminal cytosolic domain of many TRP channels. The topics addressed in this Highlight include the structural features of canonical ankyrin repeats, new clues into the functions these repeats perform in cells, and how this information can be applied to develop further experiments on TRP channels and other proteins containing ankyrin repeats.