The cancer stem cell niche: cross talk between cancer stem cells and their microenvironment
The cancer stem cell niche: cross talk between cancer stem cells and their microenvironment
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DOI：
10.1007/s13277-013-1561-x
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发表时间：
2014-01
期刊：
影响因子：
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通讯作者：
J. Ye;Dang Wu;Pin Wu;Zhigang Chen;Jian Huang
中科院分区：
文献类型：
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作者：
J. Ye;Dang Wu;Pin Wu;Zhigang Chen;Jian Huang
尽管最近肿瘤治疗取得了进展，对肿瘤生物学的认识也有所增加，但肿瘤仍然是一种常见的、致命的疾病。肿瘤干细胞(CSCs)是一类具有干细胞样能力的肿瘤细胞亚群，可促进肿瘤生长和复发，对目前的许多抗癌治疗具有耐药性。实体瘤被认为是由癌细胞和肿瘤间质组成的“器官”。肿瘤的微环境构成了肿瘤的间质，它占据了肿瘤质量的大部分，包括细胞外基质(ECM)、间充质干细胞(MSCs)、内皮细胞、免疫细胞以及细胞因子和生长因子网络。CSCs周围的微环境或利基环境在很大程度上决定了它们的细胞命运。最近的研究表明，微环境支持CSC自我更新，同时也是药物输送的物理屏障。肿瘤微环境在肿瘤发展的各个阶段起着举足轻重的作用。了解CSCs与其微环境的相互作用对于开发新的治疗策略似乎是最重要的。
Despite recent progresses in tumor therapy and increased knowledge in tumor biology, tumor remains a common and lethal disease worldwide. Cancer stem cells (CSCs) are a subset of cancer cells with a stem cell-like ability, which may drive tumor growth and recurrence and are resistant to many current anticancer treatments. Solid tumors are regarded as “organs” which are comprised of cancer cells and the tumor stroma. The tumor microenvironment makes up the stroma of the tumor, which occupies the majority of the tumor mass, including the extracellular matrix (ECM), mesenchymal stem cells (MSCs), endothelial cells, immune cells, and, what is more, networks of cytokines and growth factors. The microenvironment or niche surrounding CSCs largely governs their cellular fate. Recent work has revealed that the microenvironment supports CSC self-renewal and simultaneously serves as a physical barrier to drug delivery. The tumor microenvironment plays pivotal roles in each stage of tumor development. Knowledge about the interactions of CSCs with their microenvironment would seem to be of most importance for developing new treatment strategies.