A receptor for the third component of complement in the human renal glomerulus
A receptor for the third component of complement in the human renal glomerulus
复制标题
人肾小球补体第三种成分的受体
DOI：
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复制
发表时间：
1975
影响因子：
15.3
通讯作者：
I. Green
中科院分区：
文献类型：
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作者：
M. Gelfand;M. Frank;I. Green
在研究人肾组织切片中单核细胞浸润的性质的过程中，注意到指示绵羊红细胞致密地包被有补体的第三组分（C3），特异性地粘附于组织切片中的所有肾小球。补体（C）在肾小球内的沉积是许多免疫相关性肾脏疾病的特征（1，2），但C沉积的确切机制仍无法解释。因此，我们认为，这一观察结果表明存在C受体，特别令人感兴趣。
In the course of studying the nature of mononuclear cellular infiltrates in tissue sections of human kidney it was noted that indicator sheep erythrocytes densely coated with the third component of complement (C3) specifically adhered to all of the glomeruli in the tissue sections. The deposition of complement (C) within the glomerulus is a feature of many immunologically related renal diseases (1,2), yet the precise mechanism by which C is deposited remains unexplained. We feel that this observation, suggesting the presence of a receptor for C, is, therefore, of particular interest.