Mitogen-activated protein kinase activation in UV-induced signal transduction.
Mitogen-activated protein kinase activation in UV-induced signal transduction.
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DOI：
10.1126/stke.2003.167.re2
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发表时间：
2003-01-28
期刊：
影响因子：
--
通讯作者：
Dong, Zigang
中科院分区：
文献类型：
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作者：
Bode, Ann M;Dong, Zigang
流行病学结果支持的实验证据表明，太阳紫外线(UV)辐射是导致皮肤癌发生的最重要的环境致癌物质。由于臭氧层阻挡了UVC(波长180到280 nm)的照射，UVA(UVA I，340到400 nm；UVA II，320到340 nm)和UVB(280到320 nm)可能是阳光中与人类皮肤癌相关的主要致癌成分。在过去的几年里，人们在阐明紫外线诱导的皮肤癌发生中所涉及的特定信号转导途径方面做出了很大的贡献，大多数证据表明细胞的信号反应是紫外线波长依赖的。丝裂原活化蛋白激酶(MAPK)信号通路是紫外线的靶标，在调节紫外线诱导的多种细胞反应中起重要作用。实验研究使用了不同剂量的UVA、UVB、UVC及其不同的组合，观察到的对MAPK激活和磷酸化的影响是不同的。本文综述了支持MAPKs在紫外线诱导的皮肤癌发生中作用的机制数据。在了解紫外线诱导的信号转导机制方面的进展可能导致使用这些蛋白激酶作为预防和控制皮肤癌的特定靶点。
Experimental evidence supported by epidemiological findings suggests that solar ultraviolet (UV) irradiation is the most important environmental carcinogen leading to the development of skin cancers. Because the ozone layer blocks UVC (wavelength, 180 to 280 nm) exposure, UVA (UVA I, 340 to 400 nm; UVA II, 320 to 340 nm) and UVB (280 to 320 nm) are probably the chief carcinogenic components of sunlight with relevance for human skin cancer. Substantial contributions to the elucidation of the specific signal transduction pathways involved in UV-induced skin carcinogenesis have been made over the past few years, and most evidence suggests that the cellular signaling response is UV wavelength-dependent. The mitogen-activated protein kinase (MAPK) signaling cascades are targets for UV and are important in the regulation of the multitude of UV-induced cellular responses. Experimental studies have used a range of UVA, UVB, UVC, and various combinations in multiple doses, and the observed effects on activation and phosphorylation of MAPKs are varied. This review focuses on the mechanistic data supporting a role for MAPKs in UV-induced skin carcinogenesis. Progress in understanding the mechanisms of UV-induced signal transduction could lead to the use of these protein kinases as specific targets for the prevention and control of skin cancer.