Cancer Stem Cells: A Moving Target.
Cancer Stem Cells: A Moving Target.
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癌症干细胞：一个移动的靶标。
DOI：
10.1007/s40139-013-0010-2
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发表时间：
2013-06-01
影响因子：
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通讯作者：
Lagasse E
中科院分区：
文献类型：
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作者：
Francipane MG;Chandler J;Lagasse E
尽管近年来进入临床试验并获得FDA批准的抗癌药物数量有所增加，但许多癌症患者的生存结果仍然很差。对这种令人沮丧的预后的主要解释是，目前的治疗可能会留下一群具有长期自我更新能力的癌细胞，即所谓的癌症干细胞（CSC），大多数肿瘤被认为是来源和燃料。CSC可能有利于局部和远处复发，甚至在初始治疗后许多年，因此代表了旨在改善临床结果的治疗的潜在靶点。在这篇综述中，我们将讨论CSC假说，特别强调其目前的范式和辩论，并讨论CSC对传统疗法的耐药性的几种机制。
Even though the number of anti-cancer drugs entering clinical trials and approved by the FDA has increased in recent years, many cancer patients still experience poor survival outcome. The main explanation for such a dismal prognosis is that current therapies might leave behind a population of cancer cells with the capacity for long-term self-renewal, so-called cancer stem cells (CSCs), from which most tumors are believed to be derived and fueled. CSCs might favor local and distant recurrence even many years after initial treatment, thus representing a potential target for therapies aimed at improving clinical outcome. In this review, we will address the CSC hypothesis with a particular emphasis on its current paradigms and debates, and discuss several mechanisms of CSC resistance to conventional therapies.