G Protein-Coupled Receptor Structures, Molecular Associations, and Modes of Regulation
G Protein-Coupled Receptor Structures, Molecular Associations, and Modes of Regulation
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DOI：
10.1196/annals.1418.000
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发表时间：
2008-01-01
期刊：
影响因子：
--
通讯作者：
Miller, Laurence J.
中科院分区：
文献类型：
--
作者：
Miller, Laurence J.
G蛋白偶联受体存在于体内每一个可兴奋和可调节的细胞上，是药物作用的重要潜在位点。这组分子已经代表了目前批准的药物最常见的靶标。随着我们对这些受体的详细分子结构、激活机制、独特的分子关联以及调节这些受体的细胞和生化机制的理解的最新进展，受体活性药物的开发和改进将大大受益。在本报告中，回顾了过去的主要成就和未来可能的研究方向。
G protein-coupled receptors are present on every excitable and regulatable cell in the body and represent important potential sites for drug action. This group of molecules already represents the most common target for currently approved drugs. With recent advances in our understanding of detailed molecular structure, mechanisms of activation, unique molecular associations, and cellular and biochemical mechanisms of regulation of these receptors, development and refinement of receptor-active drugs should benefit substantially. In this report, key past accomplishments and possible future directions for this field of research are reviewed.