Self‐ assembly of block copolymers for biological applications
Self‐ assembly of block copolymers for biological applications
复制标题
用于生物应用的嵌段共聚物的自组装
DOI：
10.1002/pi.6327
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发表时间：
2022
影响因子：
3.2
通讯作者：
Lin, Zhiqun
中科院分区：
文献类型：
--
作者：
Li, Zili;Lin, Zhiqun
在过去的几十年里，嵌段共聚物(BCP)的自组装由于一系列有趣的性质而引起了人们的极大关注。从这一角度出发，介绍了不同结构的BCP在自组装和应用方面的最新进展。首先，介绍了BCP的自组装机理和评价组装形态的一般标准。随后，讨论了线型、星型和瓶刷型BCP的自组装。特别强调了聚合诱导自组装在大规模制备中的应用。然后，概述了自组装双环蛋白在药物递送、生物成像、分子识别和光热治疗等方面的广泛应用。最后，对生物用自组装BCP的大规模生产和实施进行了展望。©2021工业化学学会。
Self‐assembly of block copolymers (BCPs) has garnered much attention over the past several decades owing to an array of intriguing properties. In this perspective, recent advances in self‐assembly and applications of BCPs with different architectures are presented. First, the self‐assembly mechanism of BCPs and the general criteria to evaluate the assembled morphologies are introduced. Subsequently, the self‐assembly of linear, star‐like and bottlebrush‐like BCPs is discussed. In particular, polymerization‐induced self‐assembly for large‐scale preparation is highlighted. Afterwards, a rich diversity of applications of self‐assembled BCPs in drug delivery, bioimaging, molecular recognition and photothermal therapy are outlined. Finally, an outlook on larger‐scale production and implementation of self‐assembled BCPs for biological applications is noted. © 2021 Society of Industrial Chemistry.