Glycoprotein nonmetastatic melanoma protein B: A key mediator and an emerging therapeutic target in autoimmune diseases.
Glycoprotein nonmetastatic melanoma protein B: A key mediator and an emerging therapeutic target in autoimmune diseases.
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DOI：
10.1096/fj.202000651
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发表时间：
2020-07
期刊：
影响因子：
--
通讯作者：
Sawalha AH
中科院分区：
文献类型：
--
作者：
Tsou PS;Sawalha AH
糖蛋白非转移性黑色素瘤蛋白B （GPNMB，也称为骨激活素）在许多细胞类型中高度表达，并调节各种组织的稳态。在不同的生理环境下，它作为黑色素体相关蛋白、膜结合表面受体、可溶性配体或粘附分子发挥作用。因此，它参与细胞分化、迁移、炎症、代谢和神经保护。由于GPNMB参与不同的生理条件，它与许多疾病有关，包括癌症、神经系统疾病和最近的免疫介导性疾病。本文综述了GPNMB在正常生理中的调节和功能，并讨论了GPNMB在疾病中的作用，特别关注其在自身免疫中的潜在作用和治疗意义。
The glycoprotein nonmetastatic melanoma protein B (GPNMB, also known as osteoactivin) is highly expressed in many cell types and regulates the homeostasis in various tissues. In different physiological contexts, it functions as a melanosome-associated protein, membrane-bound surface receptor, soluble ligand, or adhesion molecule. It is therefore involved in cell differentiation, migration, inflammation, metabolism, and neuroprotection. Because of its various involvement in different physiological conditions, GPNMB has been implicated in many diseases, including cancer, neurological disorders, and more recently immune-mediated diseases. This review summarizes the regulation and function of GPNMB in normal physiology, and discusses the involvement of GPNMB in disease conditions with a particular focus on its potential role and therapeutic implications in autoimmunity.
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