Consequences of telomerase inhibition by BIBR1532 on proliferation and chemosensitivity of chondrosarcoma cell lines
Consequences of telomerase inhibition by BIBR1532 on proliferation and chemosensitivity of chondrosarcoma cell lines
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DOI：
10.1080/07357900802072905
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发表时间：
2008-01-01
影响因子：
2.4
通讯作者：
Fellenberg, J.
中科院分区：
文献类型：
--
作者：
Parsch, D.;Brassat, U.;Fellenberg, J.
目的：人类软骨肉瘤通常对常规治疗如化疗和放疗有抵抗力。我们研究了端粒酶抑制剂BIBR1532对软骨肉瘤细胞的作用。方法：分析BIBR1532处理后软骨肉瘤细胞株端粒酶活性、端粒长度、生长动力学和化疗敏感性。结果如下：BIBR1532处理导致端粒酶抑制、端粒长度减少和端粒酶阳性软骨肉瘤细胞生长能力降低。尽管对顺铂耐药，但端粒酶阳性细胞对紫杉醇敏感，紫杉醇迅速诱导端粒侵蚀。结论：靶向端粒可能是一种有效的策略，（再）敏感化耐药软骨肉瘤。
Purpose: Human chondrosarcomas are generally resistant to conventional treatments like chemotherapy and radiotherapy. We investigated the effects of BIBR1532, an inhibitor of telomerase on chondrosarcoma cells in vitro. Methods: Telomerase activity, telomere lengths, growth kinetics and chemosensitivity were analyzed in chondrosarcoma cell lines treated with BIBR1532. Results: BIBR1532 treatment resulted in telomerase inhibition, decrease of telomere length and reduction of growth capacity of telomerase positive chondrosarcoma cells. Although resistant to cisplatin, telomerase positive cells were sensitive to paclitaxel, which rapidly induced telomere erosion. Conclusion: Targeting of telomeres might represent a valid strategy for the (re-)sensitization of chemoresistant chondrosarcomas.