CHANGES IN BONE-MARROW BLOOD-FLOW WITH AGING
CHANGES IN BONE-MARROW BLOOD-FLOW WITH AGING
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DOI：
10.1002/jor.1100050412
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发表时间：
1987-01-01
影响因子：
2.8
通讯作者：
HIROHATA, K
中科院分区：
文献类型：
--
作者：
KITA, K;KAWAI, K;HIROHATA, K
我们研究了家兔骨髓血流量和组织学随增龄的变化。通过氢冲洗法测量骨髓血流量，该方法在3-42月龄日本白色家兔胫骨近端进行。骨髓血流量随着年龄的增长而减少。胫骨近端的组织学观察发现成骨细胞和造血细胞数量减少，空骨陷窝数量增加，骨形成率降低，骨髓脂肪随着年龄的增长而退化。这些结果表明，骨髓血流量的减少与衰老所发现的组织学变化有关。
We investigated changes in bone marrow blood flow and histology with aging in rabbits. Bone marrow blood flow was measured by the hydrogen washout method, which was performed in the proximal tibia of Japanese white rabbits, 3-42 months of age. Bone marrow blood flow was found to decrease with age. Histological observations of the proximal tibia identified a decrease in the number of osteoblasts and hematopoietic cells, an increase of the number of empty lacunae, a reduction in bone formation rate, and a degeneration of marrow fat with aging. These results suggest that the decrease of bone marrow blood flow is related to histological changes found with aging.