Effect of hypotension on liver blood flow and lidocaine disposition.
Effect of hypotension on liver blood flow and lidocaine disposition.
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低血压对肝血流量和利多卡因分布的影响。
DOI：
10.1056/nejm198209303071406
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发表时间：
1982
期刊：
影响因子：
--
通讯作者：
Robertson,D
中科院分区：
文献类型：
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作者：
Feely,J;Wade,D;McAllister,CB;Wilkinson,GR;Robertson,D
与其他血管丰富的器官相比，肝脏在存在舒张时自动调节血流的能力有限。1这可能对肝脏高度提取的药物（如利多卡因、哌替啶、吗啡和普萘洛尔）的清除产生重要影响，这些药物的全身清除依赖于肝脏血流。2，3因此，在充血性心力衰竭中，4在肝血流量福尔斯与心输出量减少成比例的情况下，5和在动物实验性出血引起的低血压中，6利多卡因的清除率显著降低。由于这些药物通常用于......
IN comparison to other highly vascular organs, the liver has a limited ability to autoregulate blood flow in the presence of hypotension.1This may have important consequences for the clearance of drugs that are highly extracted by the liver, such as lidocaine, meperidine, morphine, and propranolol, and whose systemic elimination is dependent on liver blood flow.2,3Thus, in congestive heart failure,4in which liver blood flow falls in proportion to the reduction in cardiac output,5and in experimental hypotension due to hemorrhage in animals,6the clearance of lidocaine is markedly reduced. Since these drugs are commonly given to patients with . . .