High Level Serum Procalcitonin Associated Gouty Arthritis Susceptibility: From a Southern Chinese Han Population.
High Level Serum Procalcitonin Associated Gouty Arthritis Susceptibility: From a Southern Chinese Han Population.
复制标题
高水平血清降钙素原相关痛风性关节炎易感性：来自中国南方汉族人群
DOI：
10.1371/journal.pone.0132855
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发表时间：
2015
期刊：
影响因子：
3.7
通讯作者：
Shi G
中科院分区：
文献类型：
--
作者：
Liu W;Sigdel KR;Wang Y;Su Q;Huang Y;Zhang YL;Chen J;Duan L;Shi G
目的探讨降钙素原（PCT）在中国南方汉族人群痛风性关节炎（GA）、类风湿性关节炎（RA）和无感染的强直性脊柱炎（AS）中的临床意义。从2012年2月至2015年2月，51例GA患者、37例RA患者、41例AS患者和33例健康对照入组本研究，无感染证据。采用电化学发光免疫分析法（ECLIA）测定血清PCT水平（正常范围<0.05ng/ml）。GA组VAS评分为（4.07 ± 1.15）分，RA组为（4.97 ± 1.12）分，AS组为（2.97 ± 0.81）分。其他实验室指标如血清肌酐（CRE）、红细胞沉降率（ESR）、C反应蛋白（CRP）、尿酸（UA）和白色血细胞（WBC）均从病历系统中提取。痛风性关节炎患者血清PCT水平明显高于RA和AS患者，尤其是GA合并痛风石患者。痛风性关节炎患者PCT与VAS、CRP、ESR呈显著正相关，AS患者CRP与VAS、CRP呈显著正相关。RA和AS患者PCT与ESR、DAS 28和ASDAS均呈正相关，但无显著性差异。这些数据表明，PCT不仅是感染的生物标志物，也是炎症性关节炎，特别是痛风性关节炎的指标。
To study the serum Procalcitonin (PCT) level in inflammatory arthritis including gouty arthritis (GA), Rheumatoid arthritis (RA), and ankylosing spondylitis (AS) without any evidence of infection were evaluated the possible discriminative role of PCT in gouty arthritis susceptibility in southern Chinese Han Population. From Feb, 2012 to Feb, 2015, 51 patients with GA, 37 patients with RA, 41 patients with AS and 33 healthy control were enrolled in this study with no evidence of infections. The serum level of PCT (normal range < 0.05 ng/ml) was measured by electrochemiluminescence immunoassay (ECLIA). Disease activity was determined by scores of VAS (4.07 ± 1.15), DAS28 (4.97 ± 1.12), and ASDAS (2.97 ± 0.81) in GA, RA and AS groups respectively. Other laboratory parameters such as, serum creatinine (CRE), erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), uric acid (UA) and white blood cells (WBC) were extracted from medical record system. Serum PCT level was predominantly higher in gouty arthritis than in RA and AS patients, especially in the GA patients with tophi. PCT was significantly positively correlated with VAS, CRP and ESR in gouty arthritis and CRP in AS. PCT also had positive correlation-ship with ESR, DAS28 and ASDAS in RA and AS patients respectively, but significant differences were not observed. These data suggested that PCT is not solely a biomarker for infection, but also an indicator in inflammatory arthritis, especially in gouty arthritis.