5-HT2 receptor agonists increase spontaneous sympathetic nerve discharge.
5-HT2 receptor agonists increase spontaneous sympathetic nerve discharge.
复制标题
5-HT2受体激动剂增加自发交感神经放电。
DOI：
10.1016/0014-2999(88)90698-x
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发表时间：
1988
影响因子：
5
通讯作者：
L. T. Harris
中科院分区：
文献类型：
--
作者：
Robert B. McCall;L. T. Harris
选择性5-HT_2激动剂1-（2，5-二甲氧基-4-碘苯基）-2-氨基丙烷（DOI）能使氯醛糖麻醉猫心下神经交感神经自发放电明显增加。DOI（0.01-1.0 mg/kg i.v.）增加交感神经放电至对照值的最大1750%。DOI引起的交感神经放电增加可被5-HT 2拮抗剂酮色林和LY 53857逆转。此外，预处理酮色林，而不是哌唑嗪，完全阻止了增加交感神经放电产生的DOI。这些数据进行了讨论的关系中的作用，5-羟色胺在中枢交感神经通路的活动的调节。
The selective 5-HT2agonist 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (DOI) produced a marked increase in spontaneous sympathetic nerve discharge recorded from the inferior cardiac nerve in chloralose anesthetized cats. DOI (0.01–1.0 mg/kg i.v.) increased sympathetic nerve discharge to a maximum of 1750% of control values. The increase in sympathetic nerve discharge produced by DOI was reversed by the 5-HT2antagonists ketanserin and LY 53857. In addition, pretreatment with ketanserin, but not prazosin, completely prevented the increase in sympathetic nerve discharge produced by DOI. These data are discussed in relationship to the role of serotonin in the regulation of activity in central sympathetic pathways.